摘要
The anti-malarial effect of an aqueous extract of Cymbopogon citratus, a Nigerian traditional medicinal plant, has been investigated in mice infected with plasmodium yoelii nigeriensis. The plant extract was found effective in suppressing malarial infection. Infected animals, orally given in drinking water 0.106 – 0.473 g ml-1 of the extract for 5 consecutive days after the disease had been established, were observed to be cleared of the malarial parasites 4 days after commencement of treatment. The mice, however, lived thereafter, for another 8-10 days before dying because only a low number of non-parasitized red-blood cells were left in the circulation. When on the other hand, the crude salt was injected i. p in doses of 1.0-1.5 g kg-1 for 3 consecutive days, it suppressed the infection during and 2 days after the extract treatment, at which time it was observed that the erythrocyte infection rate (EIR) started rising until the animals died at about 8 days post-treatment, that is, they survived 5-6 days longer than the non-treated (control animals). Chemoprophylactic action of the extract injected i. p prior to infection gave protection for about 72 hours. No adverse reactions were recorded when the drug plant was given orally, but certain reactions were noted when administered i. p to which they survived. The drug plant given i. p has an LD50 of 2.32 g kg-1 and the plant is schizontocidal in action. Chemical analysis of the extract revealed presence of alkaloids, saponins, tannins and simple sugars.
摘要译文
尼日利亚传统药物cymbopogon citratus水提取物的抗疟疾作用已在感染尼日利亚疟原虫的小鼠中研究。发现该植物提取物可有效抑制疟疾感染。在疾病结束后连续5天，在饮用水中口服0.106 - 0.473 g ML-1的感染动物被观察到开始治疗后4天已清除疟疾寄生虫。然而，此后，小鼠在死亡前再过8-10天，因为只剩下较少的非寄生红血细胞。另一方面，将粗盐注入i。p连续3天，剂量为1.0-1.5 g kg-1，在提取物治疗后的2天内抑制了感染，截至此时，观察到红细胞感染率（EIR）开始上升，直到动物在治疗后8天死亡，即在5-6天后长5-6天，它们的生存时间比未摄入的动物（对照动物）长5-6天。提取物注入的化学预防作用i。p在感染之前给予保护约72小时。口服药物植物时未记录不良反应，但是施用i时会发现某些反应。他们幸存下来的p。药厂给予i。P的LD50为2.32 g kg-1，该植物的作用是精神分裂的。提取物的化学分析揭示了生物碱，皂苷，单宁和简单糖的存在。
A.O. ONABANJO; E. O. AGBAJE; O. O. ODUSOTE. Effects of Aqueous Extracts of Cymbopogon citratus in Malaria[J]. The Journal of Protozoology Research, 1993,3(2): 40-45