摘要
Purpose
To analyze the effect of combined application of intravaginal PGE2 insert and intracervical Foley balloon catheter for induction of labor.Methods
Patients with unfavorable cervices who required induction of labor from August 2017 to December 2017 were evaluated for the study. Three hundred and ten participants were randomly assigned to study (n:155) and control group (n:155). Nine patients in study group and seven patients in control group were excluded, because they declined to participate in the study. Totally, 294 women analyzed in this prospective randomized study: Group 1 (control group): labor induction with intravaginal PgE2 vaginal insert alone (n = 148) and Group 2 (study group): intracervical Foley balloon catheter insertion adjunct to the intravaginal PgE2 insert (n = 146). The primary outcome of our study was the period from induction to delivery. The secondary outcome was the period from induction to active phase of labor.Results
In the analysis of primiparous pregnants, combination of intracervical Foley balloon catheter and intravaginal PgE2 insertion was shown to be associated with shorter duration from induction to active stage of labor (1000 vs. 585 min, P < 0.001) and also to delivery (1386 vs. 1001 min, P < 0.001). Groups were found to be similar in terms of duration from induction to active stage of labor (670.5 vs. 535.2, P > 0.05) and also to delivery (933.1 vs. 777.9, P > 0.05, Table 2) in subgroup of women with the previous vaginal delivery.Conclusions
Combined application of intracervical Foley balloon catheter and intravaginal PgE2 insert may result in a shorter time from labor induction to delivery without rising the risk of cesarean section in primiparous women with an unfavorable cervix.
摘要译文
目的：分析阴道内PGE2插入物与宫颈内Foley球囊导管联合应用对引产的影响。方法对2017年8月至2017年12月需要引产的不良宫颈患者进行评估。随机分配了310名参与者进行研究（n = 155）和对照组（n = 155）。研究组中有9名患者和对照组中有7名患者被排除在外，因为他们拒绝参加该研究。总共有294名女性在这项前瞻性随机研究中进行了分析：第1组（对照组）：仅用阴道内PgE2阴道插入物（n = 148）和第2组（研究组）进行分娩：宫颈内注射Foley球囊导管插入阴道内PgE2插入物（N = 146）。我们研究的主要结果是从诱导到分娩的时期。次要结果是从分娩到分娩期。结果在初产孕妇的分析中，宫内Foley球囊导管和阴道内PgE2插入的组合显示与从诱导到活动阶段的较短持续时间相关（1000 vs. 585分钟，P <0.001）并且还递送（1386对比1001分钟，P <0.001）。从诱导到活跃分娩的持续时间（670.5 vs. 535.2，P> 0.05）以及分娩组（933.1 vs. 777.9，P> 0.05，表2）中发现各组的相似性。结论宫内Foley球囊导管和阴道内PgE2插入物的联合应用可以缩短从引产到分娩的时间，而不会增加产前子宫颈不良的剖宫产风险。
Ahmet Eser[1]]Enis Ozkaya[1]]Cigdem Yayla Abide[1]]Tugba Eser[2]]Gulcin Yildirim Eser[3]]Faruk Abike[4]]Ahter Tanay Tayyar[1]]Mustafa Eroglu[1]]. Transcervical Foley balloon catheter and vaginal prostaglandin E2 insert combination vs. vaginal prostaglandin E2 insert only for induction of labor at term: a randomized clinical trial[J]. Archives of Gynecology and Obstetrics, 2019,299(2): 451–457