摘要
Hydrogen sulfide is an antioxidant molecule that has a wide range of biological effects against oxidative stress. Balanced oxidative stress is also vital for maintaining cellular function in biological system, where reactive oxygen species are the main source of oxidative stress. When the normal redox balance is disturbed, deoxyribonucleic acid, lipid, and protein molecules are oxidized under pathological conditions, like diabetes mellitus that leads to diabetic peripheral neuropathy. In diabetes mellitus-induced diabetic peripheral neuropathy, due to hyperglycemia, pancreatic beta cell (β cell) shows resistance to insulin secretion. As a consequence, glucose metabolism is disturbed in neuronal cells which are distracted from providing proper cell signaling pathway. Not only diabetic peripheral neuropathy but also other central damages occur in brain neuropathy. Neurological studies regarding type 1 diabetes mellitus patients with Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis have shown changes in the central nervous system because high blood glucose levels (HbA1c) appeared with poor cognitive function. Oxidative stress plays a role in inhibiting insulin signaling that is necessary for brain function. Hydrogen sulfide exhibits antioxidant effects against oxidative stress, where cystathionine β synthase, cystathionine γ lyase, and 3-mercaptopyruvate sulfurtransferase are the endogenous sources of hydrogen sulfide. This review is to explore the pathogenesis of diabetes mellitus-induced diabetic peripheral neuropathy and other neurological comorbid disorders under the oxidative stress condition and the anti-oxidative effects of hydrogen sulfide.
摘要译文
硫化氢是一种抗氧化剂分子，对氧化应激具有广泛的生物学作用。平衡的氧化应激对于在生物系统中维持细胞功能也至关重要，在生物系统中，活性氧是氧化应激的主要来源。当正常的氧化还原平衡受到干扰时，脱氧核糖核酸，脂质和蛋白质分子在病理条件下被氧化，例如导致糖尿病外周神经病的糖尿病。在糖尿病中，由于高血糖症，胰腺诱导的糖尿病外周神经病，胰腺β细胞（β细胞）表现出对胰岛素分泌的耐药性。结果，葡萄糖代谢在神经元细胞中受到干扰，这些神经元细胞分心于提供适当的细胞信号通路。不仅糖尿病周围神经病，而且在脑神经病中也会发生其他中心损害。关于1型糖尿病患有阿尔茨海默氏病，帕金森氏病和肌萎缩性侧索硬化症患者的神经学研究表明，中枢神经系统发生了变化，因为高血糖水平（HBA1C）的认知功能差。氧化应激在抑制大脑功能所必需的胰岛素信号传导中起作用。硫化氢对氧化应激表现出抗氧化剂作用，其中胱硫醚β合酶，胱磷酸酪氨酸γ裂解酶和3-丙型丙酮酸硫酸盐硫酸盐硫酸盐转移酶是硫化氢的内源性来源。这篇综述是在氧化应激状态下探索糖尿病诱导的糖尿病诱导的糖尿病周围神经病和其他神经合并症的发病机理，以及硫化氢的抗氧化作用。
Rubaiya Tabassum; Na Young Jeong; MD; PhD; ; Junyang Jung; MD; PhD. Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases[J]. Neural Regeneration Research, 2020,15(2): 232-241