期刊文献

Depletion of Small HDL Subclasses Predicts Poor Survival in Liver Cirrhosis 收藏

小型HDL亚类的耗竭预测肝硬化的存活不良

原文求助发布源

作者

Anja Pammer (https://orcid.org/0000-0002-1778-5567) [1];Tobias Madl (https://orcid.org/0000-0002-9725-5231) [2];Hansjörg Habisch (https://orcid.org/0000-0001-5537-506X) [3];Jakob Kerbl-Knapp [4];Florian Rainer [5];Vanessa Stadlbauer (https://orcid.org/0000-0001-5508-8271) [6];Angela Horvath (https://orcid.org/0000-0001-7279-0628) [7];Philipp Douschan [8];Rudolf E. Stauber (https://orcid.org/0000-0002-3687-9331) [9];Gunther Marsche (https://orcid.org/0000-0002-2422-5381) [10];

作者单位

[1]Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; [2]Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; [3]BioTechMed-Graz, 8010 Graz, Austria; [4]Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, 8010 Graz, Austria; [5]Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria; [6]Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria; [7]Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria; [8]Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria; [9]Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria; [10]Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria;

发布日期

2025-5-30

页码

664

DOI

10.3390/antiox14060664

来源信息

Antioxidants ISSN：2076-3921, 2025年, 14卷, 6期, 664页

摘要

Liver cirrhosis is a complex condition characterized by oxidative stress, inflammation, and metabolic dysfunction, contributing to systemic complications and high mortality. High-density lipoprotein (HDL), particularly its small subclasses, is known for its antioxidant, anti-inflammatory, and cholesterol efflux capacities. This study examined changes in HDL subclass distribution and composition in cirrhosis and assessed their prognostic relevance for mortality. We analyzed HDL profiles using nuclear magnetic resonance spectroscopy in patients with compensated (n = 205) and decompensated (n = 158) cirrhosis, compared to healthy controls (n = 16). Across all HDL subclasses in cirrhotic patients, cholesterol content was decreased, and triglyceride levels were elevated. In particular, compensated cirrhosis was associated with a marked reduction in small and extra-small HDL particles, while large HDL levels remained unchanged. This reduction was even more pronounced in decompensated disease. Small HDL particle levels were inversely correlated with oxidative stress markers and liver dysfunction and independently predicted 12-month mortality in patients with compensated cirrhosis, even after adjusting for MELD score. In conclusion, our findings highlight a substantial depletion of small and extra-small HDL particles as a key feature of cirrhosis, linked to oxidative stress and mortality in the compensated stage.

摘要译文

肝肝硬化是一种复杂的疾病，其特征是氧化应激，炎症和代谢功能障碍，导致系统性并发症和高死亡率。高密度脂蛋白（HDL），尤其是其小亚类，以其抗氧化剂，抗炎和胆固醇外排能力而闻名。这项研究检查了肝硬化中HDL亚类分布和组成的变化，并评估了其对死亡率的预后相关性。与健康对照组相比，我们使用核磁共振光谱（n = 205）且肝硬化（n = 158）的患者（n = 16）中使用核磁共振光谱分析了HDL谱。在肝硬化患者的所有HDL亚类中，胆固醇含量降低，甘油三酸酯水平升高。特别是，补偿的肝硬化与小型和微小的HDL颗粒的显着降低有关，而大的HDL水平保持不变。这种减少在代偿性疾病中更为明显。小型HDL颗粒水平与氧化应激标志物和肝功能障碍呈负相关，即使在调整了MELD评分后，也可以独立地预测肝硬化的患者12个月的死亡率。总之，我们的发现突出了小型和小的HDL颗粒作为肝硬化的关键特征的大量耗竭，与补偿阶段中的氧化应激和死亡率有关。