期刊文献

Cold Atmospheric Plasma in Oncology: A Review and Perspectives on Its Application in Veterinary Oncology 收藏

肿瘤学中冷大气血浆：对其在兽医肿瘤学中应用的评论和观点

原文求助发布源

作者

André Gustavo Alves Holanda (https://orcid.org/0000-0002-5996-0503) [1];Luiz Emanuel Campos Francelino (https://orcid.org/0000-0002-2441-4481) [2];Carlos Eduardo Bezerra de Moura (https://orcid.org/0000-0002-7960-5373) [3];Clodomiro Alves Junior (https://orcid.org/0000-0002-5547-5922) [4];Julia Maria Matera (https://orcid.org/0000-0001-8349-1340) [5];Genilson Fernandes de Queiroz (https://orcid.org/0000-0003-4925-7862) [6];

作者单位

[1]Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, SP, Brazil; [2]Department of Animal Sciences, Federal Rural University of the Semi-Arid, Mossoró 59625-900, RN, Brazil; [3]Department of Animal Sciences, Federal Rural University of the Semi-Arid, Mossoró 59625-900, RN, Brazil; [4]Department of Natural Sciences, Mathematics and Statistics, Federal Rural University of the Semi-Arid, Mossoró 59625-900, RN, Brazil; [5]Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, SP, Brazil; [6]Department of Animal Sciences, Federal Rural University of the Semi-Arid, Mossoró 59625-900, RN, Brazil;

发布日期

2025-3-27

页码

968

DOI

10.3390/ani15070968

来源信息

Animals ISSN：2076-2615, 2025年, 15卷, 7期, 968页

摘要

Cold atmospheric plasma (CAP) is emerging as an innovative approach for cancer treatment because of its selectivity for malignant cells and absence of significant adverse effects. While modern oncological therapies face challenges such as tumor heterogeneity and treatment resistance, CAP presents itself as a low-cost and environmentally sustainable alternative. Its mechanisms of action involve reactive oxygen and nitrogen species (RONS), UV radiation, and electromagnetic fields, which induce cell death. Preclinical and clinical studies have demonstrated the efficacy of CAP, with devices such as dielectric barrier discharge (DBD) and the plasma jet developed to minimize damage to healthy cells. Some CAP devices are already approved for clinical use, showing safety and efficacy. However, the standardization of treatments remains a challenge due to the variety of devices and parameters used. Although CAP has shown promising cytotoxic effects in vitro and in animal models, especially in different cancer cell lines, further research, particularly in vivo and in veterinary medicine, is needed to optimize its clinical use and maximize its efficacy in combating cancer.

摘要译文

冷气血浆（CAP）作为癌症治疗的一种创新方法，由于其对恶性细胞的选择性和缺乏明显的不良反应。尽管现代肿瘤疗法面临诸如肿瘤异质性和耐药性之类的挑战，但CAP却将其作为低成本和环境可持续的替代品。它的作用机制涉及活性氧和氮种（RONS），紫外线辐射和电磁场，它们诱导细胞死亡。临床前研究和临床研究表明，CAP的功效，诸如介电屏障排放（DBD）之类的设备和等离子体射流为最大程度地减少对健康细胞的损害而发展。一些瓶盖设备已被批准用于临床使用，显示出安全性和功效。但是，由于所使用的各种设备和参数，治疗的标准化仍然是一个挑战。尽管CAP在体外和动物模型中表现出有希望的细胞毒性作用，尤其是在不同的癌细胞系中，但仍需要进一步的研究，尤其是体内和兽医中的研究，以优化其临床使用并最大程度地提高其在对抗癌症方面的功效。