期刊文献

Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway 收藏

褪黑激素促进玻璃化温热的小鼠生发囊泡卵母细胞的体外成熟，潜在地通过NRF2途径降低氧化胁迫

原文求助发布源

作者

Shichao Guo; Jinyu Yang; Jianpeng Qin; Izhar Hyder Qazi; Bo Pan; Shengqin Zang; Tianyi Lv; Shoulong Deng; Yi Fang; ; Guangbin Zhou

作者单位

[1]Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China; moc.kooltuo@gnapoaixad (S.G.); moc.361@01706991uynijgnay (J.Y.); moc.361@0989pjq (J.Q.); moc.361@2991napob (B.P.); moc.361@129217028qsz (S.Z.); moc.361@1120_ytl (T.L.)Find articles by Shichao Guo[1]Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of

关键词

vitrification, receptors, antioxidants, reactive oxygen species, Nrf2

关键词译文

玻璃化，受体，抗氧化剂，反应性氧物种，NRF2

发布日期

2021 Aug

DOI

10.3390/ani11082324

来源信息

Animals : an Open Access Journal from MDPI ISSN：e0030-6835, 2021年, 11卷, 8期

摘要

Simple SummaryCryopreservation of oocytes can cause high oxidative stress, reduce the quality of vitrified-warmed oocytes, and seriously hinder the application of oocyte cryopreservation technology in production and medicine. In this work, we found for the first time that melatonin can exert antioxidant effects through receptors and regulate the Nrf2 antioxidant pathway to respond to oxidative stress of vitrified-warmed oocytes, thereby improving both oocyte quality and the potential for sub

摘要译文

简单的核心核素可造成卵母细胞的氧化胁迫，降低玻璃化温卵母细胞的质量，并严重妨碍卵母细胞冷冻保存技术在生产和药物中的应用。在这项工作中，我们首次发现褪黑激素可以通过受体施加抗氧化作用并调节NRF2抗氧化途径，以应对玻璃化温卵母细胞的氧化应激，从而提高卵母细胞质量和潜力的潜力

Shichao Guo; Jinyu Yang; Jianpeng Qin; Izhar Hyder Qazi; Bo Pan; Shengqin Zang; Tianyi Lv; Shoulong Deng; Yi Fang; ; Guangbin Zhou. Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway[J]. Animals : an Open Access Journal from MDPI, 2021,11(8)