摘要
The study assessed an integrated trypanosomosis control strategy in drug-resistant hotspot villages of northern Togo. This strategy comprised (i) rational trypanocidal drug use in symptomatic cattle, (ii) vectors and ticks control by targeted bi-monthly insecticidal spraying of the lower body parts of cattle and (iii) strategic deworming with Albendazole in the beginning and the end of the rainy season. The program was implemented between June 2014 and October 2015 in four villages in northern Togo, which had been previously identified as drug resistant hotspots for diminazene diaceturate (DA) and isometamidium chloride (ISM). The integrated control strategy was implemented in eight cattle herds at risk of the disease from two villages. Twelve herds from two other villages served as controls where trypanosomosis management and deworming remained under control of the farmers. Trypanocidal drug use during the study period was recorded by the intervention team based on the farmers’ reports and own observations. Cattle herds were followed-up for trypanosomosis symptoms which were recorded at 3 to 4-month intervals, while extensive trypanosome diagnostics and recording of the packed cell volume were done before and after the intervention. Intervention herds had a significantly lower risk of trypanosome infection with a risk ratio of 0.18 (95% CI: 0.04, 0.91; p = 0.03), but no significant effect on mean packed cell volume was observed. However, trypanocidal treatments per animal per year were lower in intervention herds compared to control herds (0.3 vs 5 for DA and 0.8 vs 2 for ISM). This study demonstrates that the implementation of an integrated best-bet strategy leads to a reduced trypanosome prevalence under lowered trypanocidal use.
摘要译文
该研究评估了多哥北部耐药热点村的综合锥虫病控制策略。该策略包括（i）在有症状的牛中使用合理的杀螟虫药物，（ii）通过对牛的下半身部位进行有针对性的双月杀虫剂喷洒来控制载体和蜱，以及（iii）在开始和结束时用阿苯达唑进行策略性驱虫。雨季。该计划于2014年6月至2015年10月在多哥北部的四个村庄实施，该村庄之前已被确定为二苯基二乙酸盐（DA）和异氰酸铵（ISM）的耐药性热点。综合控制战略在两个村庄的八个牛群中实施。来自另外两个村庄的十二个牛群作为对照，其中锥虫病管理和驱虫仍然在农民的控制之下。干预小组根据农民的报告和自己的观察结果记录了研究期间的杀螟虫药物使用情况。对牛群进行随访，以便以3至4个月的间隔记录锥虫病症状，同时在干预之前和之后进行广泛的锥虫体诊断和记录的填充细胞体积。干预牛群感染锥虫病的风险显着降低，风险比为0.18（95％CI：0.04,0.91; p = 0.03），但没有观察到对平均填充细胞体积的显着影响。然而，与对照组相比，干预畜群每只动物每年的杀螟虫处理率较低（DA为0.3 vs 5，ISM为0.8 vs 2）。该研究表明，在降低的杀螟虫使用下，实施综合的最佳下注策略可以减少锥虫的流行率。
EyabaTchamdja[a][b];Peter-HenningClausen[c];Abalo EssosimnaKulo[d];KomlanBatawui[a];BurkhardBauer[c];Jan VanDen Abbeele[e];VincentDelespaux[f];AntjeHoppenheit[c];. How rational drug use reduces trypanosome infections in cattle in chemo-resistance hot-spot villages of northern Togo[J]. Acta Tropica, 2019,190: 159-165