摘要
Sunlight, despite its benefits, can pose a threat to the skin, which is a natural protective barrier. Phototoxicity caused by overexposure, especially to ultraviolet radiation (UVR), results in burns, accelerates photoaging, and causes skin cancer formation. Natural substances of plant origin, i.e., polyphenols, flavonoids, and photosynthetic pigments, can protect the skin against the effects of radiation, acting not only as photoprotectors like natural filters but as antioxidant and anti-inflammatory remedies, alleviating the effects of photodamage to the skin. Plant-based formulations are gaining popularity as an attractive alternative to synthetic filters. Over the past 20 years, a large number of studies have been published to assess the photoprotective effects of natural plant products, primarily through their antioxidant, antimutagenic, and anti-immunosuppressive activities. This review selects the most important data on skin photodamage and photoprotective efficacy of selected plant carotenoid representatives from in vivo studies on animal models and humans, as well as in vitro experiments performed on fibroblast and keratinocyte cell lines. Recent research on carotenoids associated with lipid nanoparticles, nanoemulsions, liposomes, and micelles is reviewed. The focus was on collecting those nanomaterials that serve to improve the bioavailability and stability of carotenoids as natural antioxidants with photoprotective activity.
摘要译文
尽管有好处，阳光仍会对皮肤构成威胁，这是一种天然的保护屏障。过度暴露引起的光毒性，尤其是紫外线辐射（UVR），导致燃烧，加速光照并导致皮肤癌的形成。植物起源的天然物质，即多酚，类黄酮和光合色素，可以保护皮肤免受辐射的影响，不仅是像天然过滤器这样的光保护剂，而且作为抗氧化剂和抗炎药，减轻了光子障碍的作用皮肤。基于植物的配方已成为合成过滤器的有吸引力的替代品。在过去的20年中，已经发表了大量研究，以评估天然植物产物的光保护作用，主要是通过其抗氧化剂，抗免疫性和抗免疫抑制活性来评估。这篇综述选择了有关动物模型和人体体内研究中选定的植物类胡萝卜素代表的皮肤光损伤和光保护功效的最重要数据，以及对成纤维细胞和角质形成细胞系进行的体外实验。综述了与脂质纳米颗粒，纳米乳液，脂质体和胶束相关的类胡萝卜素的最新研究。重点是收集那些用于改善类胡萝卜素作为具有光保护活性的天然抗氧化剂的纳米材料。
Jolanta Flieger (0000-0001-6881-3161) [1];Magdalena Raszewska-Famielec [2];Elżbieta Radzikowska-Büchner [3];Wojciech Flieger (0000-0002-0509-868X) [4];. Skin Protection by Carotenoid Pigments[J]. International Journal of Molecular Sciences, 2024,25(3): 1431