摘要
A double-blind randomized controlled trial compared the efficiency of prostaglandin E2 (PGE2) gel in two different vehicle forms, one solid and the other more liquid, with respect to inducing labour in women with highly unfavourable cervical states. 43 received 0.5 mg PGE2 in a solid gel (Cerviprost) and 37 received 0.5 mg PGE2 in a more liquid cellulose-gel. After one application 18 (42%) and 9 (24%), respectively, went into labour (OR 2.8; 95% confidence interval: 0.8–6.0). After two applications of the gel 91 and 76%, respectively, were in active labour or had amniotomy performed as the cervical state had improved (OR 2.9; 95% confidence interval: 0.8–10.3). It is concluded that the solid gel was more efficient and safe than the more liquid gel.
摘要译文
一项双盲随机对照试验比较了前列腺素E 2（PGE 2）凝胶在两种不同载体形式中的效率，一种是固体，另一种是液体，对于患有高度不利的宫颈状态的女性而言，它们的分娩方式较差。 43在固体凝胶（Cerviprost）中接受0.5mg PGE 2，在更液体的纤维素凝胶中接受0.5mg PGE 2。一次申请18（42％）和9（24％）分别进入分娩后（OR 2.8; 95％置信区间：0.8-6.0）。两次施用凝胶91和76％后，分别进行了积极分娩或进行了羊膜切开术，因为宫颈状态有所改善（OR 2.9; 95％置信区间：0.8-10.3）。结论是固体凝胶比更具液体的凝胶更有效和安全。
KristjarSkajaa;AstridMamsen;Niels JørgenSecher;. Influence of vehicle form on efficiency of prostaglandin E2 gel for cervical ripening[J]. European Journal of Obstetrics & Gynecology & Reproductive Biology, 1991,42(3): 177-180