期刊文献

Chinese herbal formulas for postmenopausal osteoporosis: A review of preclinical evidence on animal studies and molecular mechanism 收藏

绝经后骨质疏松症的中草药配方：动物研究和分子机制的临床前证据回顾
原文求助 发布源
作者
Jing Lin[1];Tian Lv[1];Fubo Tian[1];Yan Wang[1];Mingyan Wang[1];Wei Tang[2];Hans-Jürgen Gober[3];Xuemin Qiu[1];Dajin Li[1];Ling Wang[4]
作者单位
[1]Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China Shanghai Key Laboratory of Female Reproductive, Endocrine-Related Diseases, Shanghai 200011, P. R. China The Academy of Integrative Medicine of Fudan University, Shanghai 200032, China;[2]Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan;[3]Department of Pharmacy, Kepler University Clinic, Neuromed Campus, Linz, Austria;[4] Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China Shanghai Key Laboratory of Female Reproductive, Endocrine-Related Diseases, Shanghai 200011, P. R. China The Academy of Integrative Medicine of Fudan University, Shanghai 200032, China
关键词
Traditional Chinese medicine (TCM);Chinese herbal medicine;Chinese herbal formula;postmenopausal osteoporosis
关键词译文
中药（TCM）;中草药;中草药配方;绝经后骨质疏松症
发布日期
18 June 2018
页码
75-83
DOI
10.1142/S2575900018300023
来源信息
Traditional Medicine and Modern Medicine ISSN：2575-9000, 2018年, 01卷, 02期, 75-83页
摘要
Whether Chinese herbal formulas are effective in treatment of postmenopausal osteoporosis remains unclear. The aim of this study is to explore the experimental evidence of both in vitro and in vivo preclinical studies using Chinese herbal formulas in postmenopausal osteoporosis. Searches were applied to various databases with relevant keywords. Original in vivo and in vitro studies using Chinese herbal formulas to treat postmenopausal osteoporosis, and with full text available, were included. Er-Xian Decoction, Bu-Shen-Ning-Xin Decoction, Qing E Formula, Liuwei Dihuang Wan, and Xian-Ling-Gu-Bao Decoction, the most commonly studied formulas, were selected from the pool of Chinese medicine. The preclinical data indicated the potential use of Chinese herbal formulas in postmenopausal osteoporosis. The underlying mechanisms included bone morphogenetic protein (BMP), Wnt/β-catenin, extracellular-signal-regulated kinase/c-Jun N terminal kinase/mitogen-activated protein kinase (ERK/JNK/MAPK), estrogen receptor (ER), and osteoprotegerin/receptor activator of nuclear factor κB ligand (OPG/RANKL) signaling pathways. This study demonstrated the anti-osteoporotic effect of Chinese herbal formulas targeting different pathways in bone metabolism. Further study with adequate sample size and follow-up time, appropriate controls, and optimal blinding is required.
摘要译文
中草药配方是否有效治疗绝经后骨质疏松症仍不清楚。本研究的目的是探索在绝经后骨质疏松症中使用中草药配方进行体外和体内临床前研究的实验证据。搜索应用于具有相关关键字的各种数据库。包括使用中草药配方治疗绝经后骨质疏松症的原始体内和体外研究，并提供全文。二仙汤，补肾宁心汤，清娥方，六味地黄丸，仙灵固保汤，是最常研究的配方，均选自中药库。临床前数据表明中草药配方在绝经后骨质疏松症中的潜在用途。其基本机制包括骨形态发生蛋白（BMP），Wnt /β-catenin，细胞外信号调节激酶/ c-Jun N末端激酶/丝裂原活化蛋白激酶（ERK / JNK / MAPK），雌激素受体（ER），核因子κB配体（OPG / RANKL）信号通路的骨保护素/受体激活剂。本研究证明了针对骨代谢不同途径的中草药配方的抗骨质疏松作用。需要进一步研究足够的样本量和随访时间，适当的控制和最佳致盲。
Jing Lin[1];Tian Lv[1];Fubo Tian[1];Yan Wang[1];Mingyan Wang[1];Wei Tang[2];Hans-Jürgen Gober[3];Xuemin Qiu[1];Dajin Li[1];Ling Wang[4]. Chinese herbal formulas for postmenopausal osteoporosis: A review of preclinical evidence on animal studies and molecular mechanism[J]. Traditional Medicine and Modern Medicine, 2018,01(02): 75-83