摘要
Recent studies report that superovulation combined with intrauterine insemination (IUI) is more successful than superovulation alone, IUI alone or superovulation with intracervical insemination in couples with male subfertility. Our study evaluated two superovulation protocols in the management of male factor infertility using IUI: (A) clomiphene citrate and human chorionic gonadotropin (HCG) and (B) human menopausal gonadotropin and HCG. Fifteen couples with severe oligoasthenozoospermia (OAS) were treated with protocol A in 54 cycles, and no pregnancies were achieved. Eight of the 15 couples with severe OAS subsequently received protocol B for 24 cycles and elicited no pregnancies. Thirty-seven couples with moderate OAS received protocol A for 169 cycles, and 2 pregnancies ensued (5.4% per couple and 1.12% per cycle). Twelve of the 35 nonpregnant couples with moderate OAS then received protocol B for 31 cycles, and 4 pregnancies were recorded (33.3% per couple and 12.9% per cycle).
摘要译文
最近的研究报告说,在男性不育症夫妇中,超排卵联合宫内人工授精(IUI)比单独超排卵,单独IUI或宫腔内人工授精超排卵更为成功。我们的研究评估了两种使用IUI处理男性不育症的超排卵方案:(A)柠檬酸克罗米芬和人绒毛膜促性腺激素(HCG),以及(B)人更年期促性腺激素和HCG。方案A治疗15对重度少突性少精子症(OAS)夫妇,共54个周期,未怀孕。 15对患有严重OAS的夫妇中的8对随后接受了协议B,持续了24个周期,没有引起任何怀孕。三十七对中度OAS夫妇接受了方案A,共进行169个周期,随后发生了2次怀孕(每对夫妇为5.4%,每个周期为1.12%)。 35例中度OAS的非妊娠夫妇中有12例接受了方案B的31个周期,并记录了4例怀孕(每对夫妇33.3%,每个周期12.9%)。
Shalev E. Geslevich Y. Matilsky M. Eyali V. Ben-Ami M.. Superovulation and Intrauterine Insemination in the Treatment of Male Factor Infertility[J]. Gynecologic and Obstetric Investigation, 1995,39(1): 50-53