期刊文献

Six-Day Fasting Causes Temporary Increases in Both Antioxidant Capacity and Oxidative Stress in Healthy Young Men: A Randomized Controlled Trial 收藏

六天的禁食会导致健康年轻人的抗氧化能力和氧化应激的暂时增加：一项随机对照试验

原文求助发布源

作者

Marius Brazaitis (https://orcid.org/0000-0003-1369-7524) [1];Katerina Židonienė [2];Nerijus Eimantas [3];Rima Solianik (https://orcid.org/0000-0001-6822-4519) [4];

作者单位

[1]Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania; [2]Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania; [3]Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania; [4]Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania;

发布日期

2025-2-26

页码

269

DOI

10.3390/antiox14030269

来源信息

Antioxidants ISSN：2076-3921, 2025年, 14卷, 3期, 269页

摘要

The impact of prolonged fasting on human oxidative stress (OS) levels and antioxidant defence mechanisms remains poorly understood. The aim of this current study was to investigate the redox response to a 6-day fast in a cohort of healthy men. Twenty-six participants were randomly allocated to a 6-day complete fasting or a control trial. Sympathetic activity, substrate oxidation, redox status, blood glucose, ketones, and testosterone concentrations were assessed. Throughout the fasting period, ketone concentration and fat oxidation increased, and carbohydrate oxidation and glucose and testosterone concentrations decreased. Heart rate increased on fasting days 2 and 4 and returned to the pre-fasting level on fasting day 6. Malondialdehyde (MDA) concentration increased after fasting days 4 and 6, and this increase was accompanied by an increase in the total antioxidant capacity (TAC), but the TAC/MDA ratio remained constant. Notably, all fasting-evoked changes returned to the baseline values after resumption of the regular diet. Thus, prolonged fasting activated both antioxidant defence and OS, but the redox balance was maintained. Consistent with this response, ketone concentration and sympathetic nervous system activity increased, and testosterone concentration decreased. These variables returned to the pre-fasting state after resumption of the usual eating habits.

摘要译文

长时间禁食对人类氧化应激（OS）水平和抗氧化剂防御机制的影响仍然很少了解。这项当前研究的目的是调查一群健康男性队列中对6天快的氧化还原反应。将26名参与者随机分配为6天的完整禁食或对照试验。评估了交感神经活性，底物氧化，氧化还原状态，血糖，酮和睾丸激素浓度。在整个禁食期间，酮浓度和脂肪氧化增加，碳水化合物氧化以及葡萄糖和睾丸激素浓度降低。在禁食第6天，禁食第2天和第4天的心率提高，并在禁食第4天和第6天后恢复到前期的水平。马发醛（MDA）浓度增加，并且这种增加伴随着总抗氧化能力（TAC）的增加，但TAC/MDA比率保持不变。值得注意的是，恢复常规饮食后，所有禁食诱发的变化都恢复为基线值。因此，长时间的禁食激活了抗氧化剂防御和OS，但氧化还原平衡得到了维持。与这种反应一致，酮浓度和交感神经系统活性增加，睾丸激素浓度降低。这些变量恢复了通常的饮食习惯后，这些变量恢复到了预先的状态。

Marius Brazaitis (https://orcid.org/0000-0003-1369-7524) [1];Katerina Židonienė [2];Nerijus Eimantas [3];Rima Solianik (https://orcid.org/0000-0001-6822-4519) [4];. Six-Day Fasting Causes Temporary Increases in Both Antioxidant Capacity and Oxidative Stress in Healthy Young Men: A Randomized Controlled Trial[J]. Antioxidants, 2025,14(3): 269