摘要
A previous study in dairy cows showed some effect of feed contaminated with Fusarium mycotoxins on metabolism and immunity. A subsequent experiment investigated the effect of feedborne Fusarium mycotoxins on some immune functions in more detail. A total mixed ration (TMR) containing a blend of feedstuffs naturally contaminated with Fusarium mycotoxins was fed for 63 d to 12 mid-lactation Holstein cows with an average milk production of 36 kg/d in a completely randomized design with repeated measures including 1) control TMR and 2) contaminated TMR. Wheat, corn, hay, and corn silage were the contaminated feedstuffs. Deoxynivalenol was the major contaminant and was found in TMR at 3.5 mg/kg of dry matter. The parameters measured were 1) performance: body weight, body condition score, dry matter intake, milk production, composition and somatic cell count; 2) health: blood serum chemistry, hematology, coagulation profile, and rumen fluid ammonia levels; 3) immune function: total serum immunoglobulins (IgA, IgG, IgM), specific antibody response to ovalbumin, and neutrophil phagocytosis. Dry matter intake, body weight, milk production, and milk composition were not affected by diet. Neutrophil phagocytosis was depressed throughout the experiment in cows fed the contaminated diet. Serum sodium concentrations and osmolality were significantly elevated throughout the experiment in cows fed the contaminated diet. Primary antibody response to ovalbumin immunization was higher in cows fed the contaminated diet compared with controls. It was concluded that feed naturally contaminated with Fusarium mycotoxins can affect metabolic parameters and immune function of dairy cows.
摘要译文
之前对奶牛的研究表明，镰刀菌霉菌毒素污染的饲料对代谢和免疫有一定影响。随后的实验更详细地研究了饲料中镰刀菌霉菌毒素对一些免疫功能的影响。饲喂63 d至12头泌乳中期的荷斯坦奶牛，平均产奶量为36 kg / d，采用完全随机设计，并采用重复测量，包括1）对照TMR和2）受污染的TMR。小麦，玉米，干草和玉米青贮饲料是受污染的饲料。脱氧雪腐镰刀菌烯醇是主要污染物，在TMR中以3.5mg / kg干物质发现。测量的参数为1）性能：体重，身体状况评分，干物质摄入量，产奶量，组成和体细胞计数; 2）健康：血清化学，血液学，凝血曲线和瘤胃液氨水平; 3）免疫功能：总血清免疫球蛋白（IgA，IgG，IgM），针对卵白蛋白的特异性抗体应答和嗜中性粒细胞吞噬作用。干物质摄入量，体重，产奶量和牛奶成分不受日粮影响。在喂食受污染饮食的母牛的整个实验中，嗜中性粒细胞吞噬作用受到抑制。整个实验期间，饲喂污染饮食的奶牛的血清钠浓度和渗透压均显着升高。与对照组相比，饲喂受污染饮食的奶牛对卵清蛋白免疫的一级抗体反应较高。得出的结论是，天然污染镰刀菌毒素的饲料会影响奶牛的代谢参数和免疫功能。
S.N.Korosteleva[*];T.K.Smith[*];H.J.Boermans[†];. Effects of feed naturally contaminated with Fusarium mycotoxins on metabolism and immunity of dairy cows[J]. Journal of Dairy Science, 2009,92(4): 1585-1593