摘要
An increasing body of evidence suggests that free radicals can contribute to the pathogenesis of cardiovascular disease in general and coronary artery disease (CAD) in particular and that antioxidant nutrients may be important in their prevention. The antioxidant vitamins A, E and C and β-carotene have been most studied, although selenium and other minerals also have recognized importance. The hypothesis has been explored using descriptive and cross-sectional studies, by case-control and prospective cohort studies and in randomized clinical trials. While not entirely consistent, overall the evidence already supports the use of antioxidants in CAD. Several large-scale randomized trials currently in progress will provide more powerful evidence of the usefulness of antioxidants in both the primary and secondary prevention of CAD. This paper reviews the state of the evidence to date.
摘要译文
越来越多的证据表明，自由基一般会导致心血管疾病的发病机制，尤其是冠状动脉疾病（CAD），并且抗氧化营养素可能对预防有重要作用。尽管硒和其他矿物质也具有公认的重要性，但抗氧化维生素A，E和C以及β-胡萝卜素的研究最多。该假设已通过描述性和横断面研究，病例对照和前瞻性队列研究以及随机临床试验进行了探索。虽然不完全一致，但整体证据已经证明在CAD中使用抗氧化剂。目前正在进行的几项大规模随机试验将提供更有力的证据证明抗氧化剂在CAD的一级和二级预防中的有效性。本文回顾了迄今为止的证据状况。
Ram B Singh[1];Damien Downing[2]. Antioxidants and Coronary Artery Disease[J]. Journal of Nutritional & Environmental Medicine, 1995,5(3): 219-224