期刊文献

The role of nitric oxide in reproduction 收藏

一氧化氮在繁殖中的作用
原文求助
作者
MCCANN, S.M.
关键词
NO and synthase; NG-monomethyl-L-arginine; nitroprusside; NOergic neurons; FSH; LH; LHRH; FSHRF.
关键词译文
没有合成酶; n g -monomethyl-l-精氨酸;硝普雌乳房;明显神经元; fsh; LH; LHRH; FSHRF。
页码
1367-1379
来源信息
Brazilian Journal of Medical and Biological Research ISSN：0100-879X, 1999年, 32卷, 11期, 1367-1379页
摘要
Nitric oxide (NO) plays a crucial role in reproduction at every level in the organism. In the brain, it activates the release of luteinizing hormone-releasing hormone (LHRH). The axons of the LHRH neurons project to the mating centers in the brain stem and by afferent pathways evoke the lordosis reflex in female rats. In males, there is activation of NOergic terminals that release NO in the corpora cavernosa penis to induce erection by generation of cyclic guanosine monophosphate (cGMP). NO also activates the release of LHRH which reaches the pituitary and activates the release of gonadotropins by activating neural NO synthase (nNOS) in the pituitary gland. In the gonad, NO plays an important role in inducing ovulation and in causing luteolysis, whereas in the reproductive tract, it relaxes uterine muscle via cGMP and constricts it via prostaglandins (PG).
摘要译文
一氧化氮（NO）起着再现了至关重要的作用，在生物体中的每一级。在大脑中，它激活促黄体生成激素释放激素（LHRH）的释放。所述LHRH神经元的项目，以在脑干的配合中心和由传入神经通路轴突唤起雌性大鼠脊柱前凸反射。在男性，有活化的能释放NO的海绵体阴茎通过产生环磷酸鸟苷（cGMP）的诱导勃起NOergic端子。否还激活的LHRH的释放而达到的脑垂体并通过激活神经一氧化氮合酶（nNOS的）在脑下垂体激活促性腺激素的释放。在性腺，NO在诱导排卵和在引起luteolysis重要的作用，而在生殖道，它松弛子宫肌肉通过cGMP和经由前列腺素（PG）的收缩它。
MCCANN, S.M.. The role of nitric oxide in reproduction[J]. Brazilian Journal of Medical and Biological Research, 1999,32(11): 1367-1379