摘要
In aerobic cells, the proton gradient that drives ATP synthesis is created by three different proton pumps—membrane enzymes of the respiratory electron transport chain known as complex I, III, and IV. Despite the striking dissimilarity of structures and apparent differences in molecular mechanisms of proton pumping, all three enzymes have much in common and employ the same universal physical principles of converting redox energy to proton pumping. In this study, we describe a simple mathematical model that illustrates the general principles of redox-driven proton pumps and discuss their implementation in complex I, III, and IV of the respiratory chain.
摘要译文
在需氧细胞中，驱动ATP合成的质子梯度由三种不同的质子泵 - 称为复合物I，III和IV的呼吸电子传递链的膜酶产生。尽管结构的显着不同和质子泵浦的分子机制的明显差异，但所有三种酶都有许多共同之处，并采用相同的通用物理原理将氧化还原能转化为质子泵浦。在这项研究中，我们描述了一个简单的数学模型，它说明了氧化还原驱动的质子泵的一般原理，并讨论了它们在呼吸链复杂的I，III和IV中的实施。
Alexei A.Stuchebrukhov[1];. Redox-Driven Proton Pumps of the Respiratory Chain[J]. Biophysical Journal, 2018,115(5): 830-840