摘要
Traditionally, reactive oxygen intermediates (ROIs) were considered to be toxic by-products of aerobic metabolism, which were disposed of using antioxidants. However, in recent years, it has become apparent that plants actively produce ROIs as signaling molecules to control processes such as programmed cell death, abiotic stress responses, pathogen defense and systemic signaling. Recent advances including microarray studies and the development of mutants with altered ROI-scavenging mechanisms provide new insights into how the steady-state level of ROIs are controlled in cells. In addition, key steps of the signal transduction pathway that senses ROIs in plants have been identified. These raise several intriguing questions about the relationships between ROI signaling, ROI stress and the production and scavenging of ROIs in the different cellular compartments.
摘要译文
传统上，活性氧中间体（ROI）被认为是有氧代谢的有毒副产物，其使用抗氧化剂处理。然而，近年来，显而易见的是，植物积极地产生ROI作为信号分子以控制诸如程序性细胞死亡，非生物胁迫应答，病原体防御和系统信号传导的过程。包括微阵列研究和具有改变的ROI清除机制的突变体的开发的最新进展提供了关于如何在细胞中控制稳态水平的ROI的新见解。此外，已经鉴定了感知植物中ROI的信号转导途径的关键步骤。这些提出了几个有趣的问题，关于ROI信号，ROI压力与不同细胞区室中ROI的产生和清除之间的关系。
Ron Mittler rmittler@iastate.edu. Oxidative stress, antioxidants and stress tolerance[J]. Trends in Plant Science, 2002,7(9): 405-410