摘要
Host defense peptides are conserved components of innate immune response present among all classes of life. These peptides are potent, broad spectrum antimicrobial agents with potential as novel therapeutic compounds. Also, the ability of host defense peptides to modulate immunity is an emerging therapeutic concept since its selective modulation is a novel antiinfective strategy. Their mechanisms of action and the fundamental differences between pathogens and host cells surfaces mostly lead to a not widely extended microbial resistance and to a lower toxicity toward host cells. Biological libraries and rational design are novel tools for developing such molecules with promising applications as therapeutic drugs. © 2012 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 98: 251–267, 2012.
摘要译文
宿主防御肽保守生活的各个阶层间存在先天免疫反应的组件。这些肽是有效的，广谱抗菌剂具有潜在的新的治疗的化合物。此外，宿主防御肽的调节免疫的能力是一个新兴的治疗性的概念，因为它的选择性调制是一种新型的抗感染的策略。它们的作用机制和病原体与宿主细胞之间的根本区别表面大多导致不能广泛延伸抗微生物性，并朝向宿主细胞一个较低的毒性。生物库和合理的设计是发展这种分子有前途的应用程序作为治疗药物的新工具。 ©2012威利期刊公司生物聚合物（PEPT SCI）98：251-267，2012。
Annia Alba[1]; Carlos López-Abarrategui[2]; Anselmo J. Otero-González[2,*];. Host defense peptides: An alternative as antiinfective and immunomodulatory therapeutics†[J]. Peptide Science, 2012,98(4): 251-267