期刊文献

Manipulation of Macrophage Activities Using Liposomes 收藏

使用脂质体操纵巨噬细胞活动

原文求助发布源

作者

H. Honing[1];N. van Rooijen[2];T.K. van den Berg[2]

作者单位

[1]Department of Molecular Cell Biology, Research Institute of Immunology & Inflammation, Faculty of Medicine, Vrije University, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands;[2]Department of Molecular Cell Biology, Research Institute of Immunology & Inflammation, Faculty of Medicine, Vrije University, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands

发布日期

28 Sep 2008

页码

359-389

DOI

10.3109/08982100009031105

来源信息

Journal of Liposome Research ISSN：0898-2104, 2000年, 10卷, 4期, 359-389页

摘要

Macrophages are of critical importance in a variety of pathological conditions and selective manipulation of macrophage functions may offer new possibilities for therapy. At present, the signalling pathways that control the different activities of macrophages, including phagocytosis and inflammatory mediator production, are being resolved and selective (ant)agonists of the relevant signalling components will gradually become available. However, the activities of such signalling components are generally not restricted to macrophages and this may result in undesirable effects. We suggest that liposomes may overcome these problems by allowing the selective targeting of drugs to the interior of the macrophage in vivo. (macrophages, liposomes, phagocytosis, activation)

摘要译文

巨噬细胞在各种病理状况中至关重要，巨噬细胞功能的选择性操作可为治疗提供新的可能性。目前，正在解决控制巨噬细胞的不同活性的信号传导途径，包括吞噬作用和炎症介质产生，并且相关信号传导组分的选择性（抗）激动剂将逐渐变得可用。然而，这种信号传导组分的活性通常不限于巨噬细胞，这可能导致不希望的效果。我们建议脂质体可以通过允许药物选择性靶向体内巨噬细胞内部来克服这些问题。（巨噬细胞，脂质体，吞噬作用，激活）

H. Honing[1];N. van Rooijen[2];T.K. van den Berg[2]. Manipulation of Macrophage Activities Using Liposomes[J]. Journal of Liposome Research, 2000,10(4): 359-389