摘要
Objective: To determine whether artificial insemination with frozen donor sperm yielded a higher pregnancy rate per cycle by intracervical (ICI) or intrauterine (IUI) techniques. A meta-analysis was performed.
Data Identification: A computerized MEDLINE search of the English-language literature on artificial insemination with donor sperm was performed and augmented by a review of meeting abstract books and references in published papers.
Study Selection: Only prospective randomized studies that reported monthly fecundity rates for IUI and ICI with frozen donor sperm were included.
Data Analysis: Seven studies were identified. The odds ratios (OR) and 95% confidence intervals (CI) were determined with use of the general estimating equation method for the three studies for which raw data could be obtained. For the remaining four studies, the OR and CI were assessed with use of the published summary data. A random-effects meta-analysis was then performed.
Result: Intrauterine insemination resulted in a significantly higher monthly fecundity rate with a common OR of 2.4 (CI 1.5–3.8).
Conclusion: On the basis of this meta-analysis of the seven prospective studies, IUI results in higher pregnancy rates than ICI for frozen donor insemination.
摘要译文
目的：确定冷冻供体精子的人工授精是否通过宫颈内（ICI）或子宫内（IUI）技术获得每个周期更高的妊娠率。进行了荟萃分析。对捐献者精子人工授精的英文文献进行了MEDLINE搜索，并在发表的论文中对会议摘要书籍和参考文献进行了回顾。研究选择：只有前瞻性随机研究报道了IUI和ICI冻结供体精子的月生殖率。数据分析：确定了七项研究。优势比（OR）和95％置信区间（CI）是通过使用一般估计方程方法确定三项研究的原始数据。对于其余四项研究，OR和CI使用公布的摘要数据进行评估。然后进行随机效应荟萃分析。结果：宫内授精导致月生殖力明显较高，共同OR为2.4（CI 1.5-3.8）。结论：在对这七项前瞻性研究进行的这项汇总分析的基础上，IUI对于冷冻供者授精的妊娠率高于ICI。
Jeffrey MGoldbergM.D.[a]∗;EdwardMaschaM.S.[a][†];TommasoFalconeM.D.[a]∗;MarjanAttaranM.D.[a]∗;. Comparison of intrauterine and intracervical insemination with frozen donor sperm: a meta-analysis[J]. Fertility and Sterility, 1999,72(5): 792-795