摘要
This review briefly summarizes the scientific evidence for a possible role of antioxidants in the prevention of coronary heart disease (CHD). Antioxidants in our diet include vitamins E, C, and β-carotene, whereas selenium is an integral part of the anti oxidant enzyme glutathione peroxidase (GSHPx). Experimental evidence suggests that free-radical damage and antioxidant defence may play an important role in the development of coronary heart disease. Epidemiological studies have produced some intriguing results, but have not indicated unequivocally that a high intake of antioxidants leads to a decreased cardiovascular disease risk. We conclude that the antioxidant atherosclerosis hypothesis is promising, but that the results of long-term intervention studies are still to be awaited. Preventive action based on antioxidant supplementation is therefore not justifiable as yet. Nevertheless, the findings so far certainly do support the recommendations for a varied diet rich in vegetables and fruit.
摘要译文
本综述简要总结了抗氧化剂在预防冠心病（CHD）中可能发挥作用的科学依据。我们饮食中的抗氧化剂包括维生素E，C，和β-胡萝卜素，而硒是抗氧化酶谷胱甘肽过氧化物酶（GSHPx）的组成部分。实验证据表明，自由基损伤和抗氧化防御可能在冠心病的发展中起重要作用。流行病学研究已经产生了一些有趣的结果，但没有明确指出大量摄入抗氧化剂会导致心血管疾病风险降低。我们得出结论，抗氧化动脉粥样硬化假说是有希望的，但仍需等待长期干预研究的结果。因此，基于抗氧化剂补充的预防作用尚不合理。尽管如此，迄今为止的研究结果肯定支持多种富含蔬菜和水果的饮食建议。
Geert van Poppel[1];Alwine Kardinaal[1];Hans Princen[2];Frans J. Kok[3]. Antioxidants and Coronary Heart Disease[J]. Annals of Medicine, 1994,26(6): 429-434