摘要
Probiotics beneficially affect the health of the host via various mechanisms in the intestine. Recent developments in probiotic products have mainly been made to maximize probiotic effects in human. In this regard, probiotic products containing doubly coated or encapsulated cells, multi-species probiotics, or high viable cell number (1010 viable cells/gram or more) have been developed and are already available in the market. Until now, the majority of probiotics contain live cells but little attention has been paid to other alternative products such as heat-killed cell or bacteriocin-containing ones, which could have broad applications due to advantages over live cell-based probiotics, such as safety and stability. In addition, genetically engineered lactic acid bacteria could be of great importance in the field of alimentary health if they are carefully designed for biological safety. Although a number of probiotics are marketed by claiming health benefits, regulations for health claims will be more stringent. Therefore sufficient scientific and clinical evidences supporting the safety and efficacy of the potential probiotic strain will be required by the regulatory authority for a health claim, which thus may have a huge impact on the future probiotic market.
摘要译文
益生菌通过肠道中的各种机制有益地影响宿主的健康。益生菌产品的最新发展主要是为了使人体中的益生菌效应最大化。在这方面，已经开发了含有双重包被或包封的细胞，多种益生菌或高活细胞数（1010活细胞/克或更多）的益生菌产品，并且已经在市场上可获得。到目前为止，大多数益生菌含有活细胞，但很少关注其他替代产品，如热灭活细胞或含细菌素的细菌，由于其优于活细胞益生菌，如安全性，因此可广泛应用。和稳定。此外，基因工程乳酸菌如果经过精心设计以保证生物安全，在营养健康领域可能具有重要意义。虽然许多益生菌通过声称健康益处进行营销，但健康声明的规定将更加严格。因此，监管机构将要求提供足够的科学和临床证据来支持潜在的益生菌菌株的安全性和有效性，从而可能对未来的益生菌市场产生巨大影响。
Seo, Jae-Gu; Lee, Gwa-Soo; Kim, Jin-Eung; Chung, Myung-Jun;. Development of Probiotic Products and Challenges[J]. KSBB Journal, 2010,25(4): 303-310