摘要
The laboratory study of dracunculiasis has suffered from the lack of a suitable, readily available animal model. We have been able to experimentally infect ferrets, Mustela putorius furo, with the North American dracunculid, Dracunculus insignis. Ferrets were inoculated with 75 to 100 infective larvae and were necropsied 90 to 240 days later. Guinea worms were recovered from 10 (56%) of 18 ferrets. A total of 44 worms were recovered, for an average of 4.4 worms per infected ferret. Gravid female worms were recovered as early as 128 days postinoculation. Thirteen (87%) of 15 gravid female worms were recovered from the extremities. Living male worms were recovered at 200 days of age, indicating that not all male worms die shortly after mating. First-stage larvae recovered from gravid females as early as 200 days of age were found to be infective to the copepod. Acanthocyclops vernalis. These observations suggest that the ferret is an excellent laboratory animal for dracunculiasis research.
摘要译文
麦地那龙线虫病的实验室研究由于缺乏合适的，容易获得的动物模型而受到影响。我们已经能够通过实验感染雪貂，Mustela putorius furo，与北美dracunculid，Dracunculus insignis。用75至100只感染性幼虫接种白鼬，并在90至240天后进行尸体剖检。从18只雪貂中的10只（56％）中回收了几内亚蠕虫。共收回44只蠕虫，平均每只受感染的雪貂有4.4只蠕虫。早在接种后128天就恢复了妊娠雌性蠕虫。 15只妊娠雌性蠕虫中有13只（87％）从四肢中恢复过来。活体雄性蠕虫在200日龄时恢复，表明并非所有雄性蠕虫在交配后不久死亡。早在200日龄时从妊娠雌性中恢复的第一期幼虫被发现对桡足类具有感染性。 Acanthocyclops vernalis。这些观察表明，雪貂是一种用于麦地那龙线虫病研究的优秀实验室动物。
M. L. Eberhard (a1); E. Ruiz-Tiben (a1);S. V. Wallace (a1). Dracunculus insignis: experimental infection in the ferret, Mustela putorius furo[J]. Journal of Helminthology, 1988,62(3): 265-270