图书章节

Regulation of Bacterial Pathogenesis by Intestinal Short-Chain Fatty Acids 收藏

肠道短链脂肪酸对细菌发病机制的调控
原文求助 发布源
作者
Yvonne Sun :1;
关键词
Gut microbiota;Short-chain fatty acids;Virulence gene regulation;
关键词译文
肠道微生物群;短链脂肪酸;毒力基因调控;
发布日期
10 August 2013
页码
93-118
DOI
10.1016/B978-0-12-407672-3.00003-4
来源信息
Advances in Applied Microbiology Volume 85 ISBN：9780124076723, 2013年, 93-118页
摘要
The human gut microbiota is inextricably linked to health and disease. One important function of the commensal organisms living in the intestine is to provide colonization resistance against invading enteric pathogens. Because of the complex nature of the interaction between the microbiota and its host, multiple mechanisms likely contribute to resistance. In this review, we dissect the biological role of short-chain fatty acids (SCFA), which are fermentation end products of the intestinal microbiota, in host–pathogen interactions. SCFA exert an extensive influence on host physiology through nutritional, regulatory, and immunomodulatory functions and can also affect bacterial fitness as a form of acid stress. Moreover, SCFA act as a signal for virulence gene regulation in common enteric pathogens. Taken together, these studies highlight the importance of the chemical environment where the biology of the host, the microbiota, and the pathogen intersects, which provides a basis for designing effective infection prevention and control.
摘要译文
人体肠道微生物群与健康和疾病密不可分。生活在肠道中的共生生物的一个重要功能是提供针对入侵肠道病原体的定殖抗性。由于微生物群与其宿主之间相互作用的复杂性，多种机制可能导致抗性。在这篇综述中，我们剖析了短链脂肪酸（SCFA）的生物学作用，它是肠道微生物群的发酵终产物，在宿主 - 病原体相互作用中。 SCFA通过营养，调节和免疫调节功能对宿主生理学产生广泛影响，并且还可以影响细菌适应性作为酸胁迫的形式。此外，SCFA作为常见肠道病原体中毒力基因调节的信号。总之，这些研究突出了宿主，微生物群和病原体的生物学相交的化学环境的重要性，这为设计有效的感染预防和控制提供了基础。
Yvonne Sun :1;. Regulation of Bacterial Pathogenesis by Intestinal Short-Chain Fatty Acids. Advances in Applied Microbiology Volume 85[M].NL: ELSEVIER, 2013: 93-118