图书章节

Obesity and Adipose Tissue Microvascular Dysfunction 收藏

肥胖和脂肪组织微血管功能障碍

原文求助发布源

作者

M.G. Farb;N. Gokce;

作者单位

Boston University School of Medicine, Boston, MA, United States;

关键词

Obesity;adipose tissue;microvasculature;perivascular fat;endothelial dysfunction;visceral fat;epicardial fat;cardiometabolic dysfunction;insulin resistance;inflammation;

关键词译文

肥胖;脂肪组织;微血管;血管周围脂肪;内皮功能障碍;内脏脂肪;心外膜脂肪;心脏代谢功能障碍;胰岛素抵抗;炎症;

发布日期

6 December 2016

页码

13-23

DOI

10.1016/B978-0-12-804011-9.00005-4

来源信息

Metabolism and Pathophysiology of Bariatric Surgery ISBN：9780128040119, 2017年, 13-23页

摘要

Obesity has emerged as a major global healthcare problem with cardiovascular disease representing the leading cause of mortality in this population. Obesity is causally linked to the development of insulin resistance, diabetes mellitus, micro- and macro-vascular disease, and atherosclerosis. Adipose tissue dysfunction with overproduction of proatherogenic cytokines and adipokine dysregulation contribute to establish a low-grade systemic inflammatory state that is strongly implicated in these disease processes. This chapter will review how the adipose tissue microenvironment is associated with microvascular dysfunction characterized by abnormalities in vasodilator and angiogenic functions, which may contribute to mechanisms of adipose tissue dysfunction and consequently whole-body cardiometabolic disease.

摘要译文

肥胖已成为全球主要的医疗保健问题，心血管疾病是该人群死亡的主要原因。肥胖与胰岛素抵抗，糖尿病，微血管和大血管疾病以及动脉粥样硬化的发展有因果关系。脂肪组织功能障碍与致动脉粥样硬化细胞因子和脂肪因子失调的过量产生有助于建立低级全身炎症状态，这与这些疾病过程密切相关。本章将回顾脂肪组织微环境如何与血管扩张和血管生成功能异常的微血管功能障碍相关，这可能导致脂肪组织功能障碍的机制，从而导致全身心脏代谢疾病。

M.G. Farb;N. Gokce;. Obesity and Adipose Tissue Microvascular Dysfunction. Metabolism and Pathophysiology of Bariatric Surgery[M].NL: Elsevier, 2017: 13-23