摘要
The stability of prostaglandin E1 and dinoprostone was investigated at the extremes of the pH range (⩽3 and ⩾10) in the sequence prostaglandin E prostaglandin A prostaglandin B. The degradation rate is first order with hydrogen-ion and hydroxide-ion concentrations. Separation and analysis of the E prostaglandins were accomplished by TLC and UV spectrophotometry. At the lowest pH values and at elevated or low temperatures, significant amounts of 15-epiprostaglandin E were present. Apparent activation energies for the total dinoprostone loss, calculated from elevated temperature data, were 21 kcal/mole in the strongly acidic region and about 18 kcal/mole at pH 3. Corresponding studies in the alkaline region led to a derived Arrhenius activation energy of 15 kcal/mole with the appearance of significant amounts of 8-isoprostaglandin E. This difference in activation energies may reflect the different mechanisms operant at high and low pH values.
摘要译文
在前列腺素E前列腺素A前列腺素B序列的pH范围（⩽3和⩾10）的极端，研究了前列腺素E 1和二磷酸石的稳定性。降解率为氢离子和氢氧根离子浓度的一级。通过TLC和UV分光光度法分离和分析E前列腺素。在最低pH值和升高或低温下，存在显着量的15-表阿斯匹林前列素E。由高温数据计算，总二倍体石损失的表观活化能在强酸性区域为21千卡/摩尔，pH 3为约18千卡/摩尔。在碱性区域的相应研究导致衍生的阿仑尼乌斯活化能为15 kcal / mol，出现显着量的8-异前列腺素E.这种活化能的差异可能反映了在高和低pH值下操作的不同机制。
R. G. Stehle[*] and T. O. Oesterling[†];. Stability of prostaglandin E1 and dinoprostone (prostaglandin E2) under strongly acidic and basic conditions[J]. Journal of Pharmaceutical Sciences, 1977,66(11): 1590-1595