摘要
The free radical gas, nitric oxide is now known to be an important biological messenger in animals. Signal transmission by a gas that is produced by one cell, penetrates through membranes and regulates the function of another cell, represents new principles for signalling in biological systems. Nitric oxide is synthesised from l-arginine by enzyme nitric oxide synthase, which exists in multiple isoforms in a wide range of mammalian cells. Studies conducted in recent years point at a strong influence of NO in a wide range of reproductive functions. It is implicated in the control of gonadotrophin secretion at both hypothalamic and hypophyseal levels, LH surge mechanism, sexual behaviour, estradiol synthesis, follicle survival and ovulation. While considerable work lies ahead in unravelling the role of NO at the peripheral, cellular and molecular level in the domestic animal reproduction, findings presented in this review provide a general overview of growing appreciation of NO as a vital molecule controlling hypothalamic–pituitary–gonadal (HPG) axis.
摘要译文
现在已知自由基气体一氧化氮是动物中重要的生物信使。由一个电池产生的气体传输信号，渗透到细胞膜并调节另一个细胞的功能，代表了生物系统中信号传导的新原理。一氧化氮由L-精氨酸通过酶一氧化氮合酶合成，其在多种哺乳动物细胞中以多种同种型存在。近年来进行的研究指出，NO在广泛的生殖功能中具有强烈的影响。它与下丘脑和垂体水平的促性腺激素分泌调控，LH激增机制，性行为，雌二醇合成，卵泡存活和排卵有关。尽管在国内动物繁殖的周边，细胞和分子水平揭示NO的作用方面还有相当多的工作要做，在这篇综述中提供的研究结果提供了一个综合的概述，认为NO是控制下丘脑 - 垂体 - 性腺（HPG）轴的重要分子。
Vishwa DeepDixit;NahidParvizi;. Nitric oxide and the control of reproduction[J]. Animal Reproduction Science, 2001,65(1-2): 1-16