摘要
Crimean-Congo hemorrhagic fever virus (CCHFV) is a member of the Bunyaviridae family and Nairovirus genus. The viral genome consists of 3 RNA segments of 12 kb (L), 6.8 kb (M), and 3 kb (S). Crimean-Congo hemorrhagic fever (CCHF) is the most widespread tickborne viral infection worldwide: it has been reported in many regions of Africa, the Middle East, and Asia. The geographical distribution of CCHFV corresponds most closely with the distribution of members of the tick genera, and Hyalomma ticks are the principal source of human infection. In contrast to human infection, CCHFV infection is asymptomatic in all species. Treatment options for CCHF are limited; immunotherapy and ribavirin are effective in the treatment of CCHF; the efficacy of ribavirin in the treatment of CCHF has not yet been proven. This article reviews the history, epidemiology, clinical symptoms, pathogenesis, diagnosis, and treatment of CCHFV, as well as the development of a vaccine against it.
摘要译文
克里米亚 - 刚果出血热病毒（CCHFV）是布尼亚病毒科和奈氏病毒属的成员。病毒基因组由12kb（L），6.8kb（M）和3kb（S）的3个RNA片段组成。克里米亚 - 刚果出血热（CCHF）是全世界最广泛的蜱传播病毒感染：据报道在非洲，中东和亚洲的许多地区。 CCHFV的地理分布与蜱属的成员分布最为吻合，Hyalomma蜱是人类感染的主要来源。与人感染相比，CCHFV感染在所有物种中无症状。 CCHF的治疗方案有限;免疫治疗和利巴韦林治疗CCHF有效;利巴韦林治疗CCHF的疗效尚未得到证实。本文回顾了CCHFV的历史，流行病学，临床症状，发病机制，诊断和治疗，以及针对其的疫苗的开发。
Sara Shayan, MSc;Mohammad Bokaean, PhD;Mona Ranjvar Shahrivar, PharmD;Sadegh Chinikar, PhD. Crimean-Congo Hemorrhagic Fever[J]. Laboratory Medicine, 2015,46(3): 180-189