期刊文献

Binding of prostaglandins E1 (alprostadil), E2 (dinoprostone), F1a, and F2a (dinoprost) to human serum proteins 收藏

前列腺素E 1（Alprostadil），E 2（Dinoprostore），F 1a和F 2a（Dinoproprost）与人血清蛋白的结合
原文求助 发布源
作者
Joseph Judis
作者单位
College of Pharmacy, University of Toledo, Toledo, OH 43606
关键词
Prost-aglandins—binding to human serum proteins, equilibrium dialysis of radiolabeled prostaglandins; Protein binding—prostaglandins E1 (alprostadil), E2 (dinoprostone), F1a, and F2a (dinoprost) to human serum proteins, equilibrium dialysis of radiolabeled prostaglandins; Binding, protein—binding of prostaglandins E1 (alprostadil), E2 (dinoprostone), F1a, and F2a (dinoprost) to human serum proteins, equilibrium dialysis of radiolabeled prostaglandins; Equilibrium dialysis—of radiolabeled prostaglandins E1 (alprostadil), E2 (dinoprostone), F1a, and F2a (dinoprost) bound to human serum proteins
关键词译文
前列腺蛋白与人血清蛋白结合，放射性标记前列腺素的平衡透析;蛋白质结合前列腺素E 1（Alprostadil），E 2（Dinoprostone），F 1A和F 2A（DinoProost）对人血清蛋白，放射性标记前列腺素的平衡透析;前列腺素E 1（Alprostadil），E 2（Dinoprostore），F 1A和F 2A（DinoProost）对人血清蛋白的结合，蛋白质结合，放射性标记前列腺素的平衡透析;平衡透析的放射性标记前列腺素E 1（Alprostadil），E 2（Dinoprostore），F 1A和F 2A（DinoProost）与人血清蛋白结合的
发布日期
22 SEP 2006
页码
945-946
DOI
10.1002/jps.2600700830
来源信息
Journal of Pharmaceutical Sciences ISSN：0022-3549, 1981年, 70卷, 8期, 945-946页
摘要
Prostaglandins E1 (alprostadil), E2 (dinoprostone), F1a, and F2a (dinoprost) were characterized in terms of binding to human serum, albumin, -globulin II, β-globulin III, -globulin IV-1, and -globulin IV-4. By using equilibrium dialysis and tritium-labeled ligands, the percent binding for all four ligands was found to decrease in the following order: human serum, albumin, and -globulin IV-4. For the other three proteins, the order was not consistent with the four ligands, and <10% binding was observed. In general, prostaglandins E1 and E2 showed a higher percent binding for all fractions than prostaglandins F1a and F2a. All four ligands can be characterized as showing significant binding to human serum, albumin, and -globulin IV-4.
摘要译文
前列腺素E 1（前列地前列腺素），E 2（dinoprostone），F 1a和F 2a（依诺前列素）的特征在于与人血清，白蛋白，球蛋白II，β-球蛋白III，球蛋白IV-1和 - 球蛋白IV-4。通过使用平衡透析和氚标记的配体，发现所有四种配体的结合百分比按以下顺序降低：人血清，白蛋白和球蛋白IV-4。对于其他三种蛋白质，顺序与四种配体不一致，观察到10％结合。通常，前列腺素E 1和E 2显示出比前列腺素F 1a和F 2a对所有级分的结合百分比更高。所有四种配体可以表征为显示与人血清，白蛋白和球蛋白IV-4的显着结合。
Joseph Judis. Binding of prostaglandins E1 (alprostadil), E2 (dinoprostone), F1a, and F2a (dinoprost) to human serum proteins[J]. Journal of Pharmaceutical Sciences, 1981,70(8): 945-946