摘要
Host defense peptides can modulate the innate immune response and boost infection-resolving immunity, while dampening potentially harmful pro-inflammatory (septic) responses. Both antimicrobial and/or immunomodulatory activities are an integral part of the process of innate immunity, which itself has many of the hallmarks of successful anti-infective therapies, namely rapid action and broad-spectrum antimicrobial activities. This gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections. This review details the role and activities of these peptides, and examines their applicability as development candidates for use against bacterial infections.
摘要译文
宿主防御肽能调节先天性免疫应答和增加感染分辨免疫，而润湿潜在有害的促炎（脓毒性）的反应。既抗微生物和/或免疫调节活性是先天免疫的过程中，其自身具有许多成功的抗感染疗法，即快速作用和广谱抗菌活性的标志的一个组成部分。这使这些肽成为对抗细菌感染的全新治疗方法的潜力。这一审查将详细介绍这些肽的作用和活动，并探讨其适用性作为开发候选人对抗细菌感染的使用。
Lars Steinstraesser [1] , Ursula M. Kraneburg [1] , Tobias Hirsch [1] , Marco Kesting [2] , Hans-Ulrich Steinau [1] , Frank Jacobsen [1] ;Sammy Al-Benna [1]. Host Defense Peptides as Effector Molecules of the Innate Immune Response: A Sledgehammer for Drug Resistance?[J]. International Journal of Molecular Sciences, 2009,10(9): 3951-3970