期刊文献

Evolutionary genetics of ruminant lysozymes 收藏

反刍动物溶菌酶的进化遗传学

原文求助发布源

作者

D. M. IRWIN[1];E. M. PRAGER[1];A. C. WILSON[1];

作者单位

[1]Division of Biochemistry and Molecular Biology, University of California, Berkeley, California, USA

关键词

lysozyme;ruminant;adaptive evolution;multigene families;gene duplication;digestion

关键词译文

溶菌酶;反刍动物;适应性进化;多基因家族;基因复制;消化

发布日期

June 1992

页码

193-202

DOI

10.1111/j.1365-2052.1992.tb00131.x

来源信息

Animal Genetics ISSN：0268-9146, 1992年, 23卷, 3期, 193-202页

摘要

Summary. Comparative studies of mammalian lysozymes and their genes have contributed to knowledge of how new functions arise during evolution. The recruitment of lysozymes for functioning in the stomach fluid of ruminants has occurred in response to selection pressures that are partly known and on a time‐scale that is known. A semiquantitative analysis of adaptive evolution is thus made possible by the ruminant lysozyme system. Large‐scale production of lysozyme by the stomach lining entailed gene duplication as well as a change in gene expression. Remoulding of the lysozyme for working and lasting in the stomach fluid involved accelerated amino acid replacements, which may have been facilitated by intergenic recombination. The possibility that multigene families can accelerate adaptive evolution, by virtue of their capacity for bringing together functionally coupled substitutions, receives emphasis in this review.

摘要译文

概要。哺乳动物溶菌酶及其基因的比较研究有助于了解进化过程中新功能如何产生的知识。为了响应部分已知的选择压力和在已知的时间尺度上，招募了用于在反刍动物的胃液中起作用的溶菌酶。因此，反刍动物溶菌酶系统使得适应性进化的半定量分析成为可能。通过胃内膜大规模生产溶菌酶需要基因复制以及基因表达的改变。用于工作并在胃液中持久的溶菌酶的重塑涉及加速的氨基酸置换，这可能通过基因间重组而得到促进。多基因家族可以加速适应性进化的可能性，凭借它们将功能上耦合的替代物汇集在一起的能力，在本文中得到强调。

D. M. IRWIN[1];E. M. PRAGER[1];A. C. WILSON[1];. Evolutionary genetics of ruminant lysozymes[J]. Animal Genetics, 1992,23(3): 193-202