摘要
Background. Asthma is an important co-morbidity of obesity. This study evaluated the impact of bariatric surgery on respiratory function in obese patients and compared the outcomes in asthmatic and non-asthmatic subjects. Methods. The study was observational and prospective and included subjects on waiting list for bariatric surgery. Pulmonary function, symptoms, and exhaled nitric oxide were assessed before surgery and 1 year after. Results. Twenty-nine severe obese subjects (age range: 25–66 years) with a mean body mass index of 44.8 ± 4.7 kg/m2 were included. Fourteen of them had also intermittent to moderate asthma. In the whole population, the body mass index decreased from 44.8 ± 4.7 to 41.1 ± 3.9 kg/m2 (p = .0001) and the forced vital capacity increased from 3.05 ± 0.83 to 3.50 ± 0.81 L (p = .043). No change was seen in forced expiratory volume and oxygen saturation. These results remained valid also analyzing asthmatics and non-asthmatics separately. Concerning nitric oxide, the decrease at 1 year was significantly different between the two populations, since in asthma patients exhaled nitric oxide decreased by 4.86 ppb after bariatric surgery and increased by 0.27 ppb in non-asthmatics (p = .04). Conclusions. Bariatric surgery significantly reduces the intake of inhaled corticosteroids and the levels of exhaled nitric oxide, thus bronchial inflammation, in asthmatics.
摘要译文
背景。哮喘是肥胖的重要并发症。本研究评估了减肥手术对肥胖患者呼吸功能的影响，并比较了哮喘和非哮喘患者的结果。方法。这项研究是观察性和前瞻性的，包括减肥手术等待名单上的受试者。肺功能，症状，并在手术前和1年后评估呼出气一氧化氮。结果。 29名重度肥胖受试者（年龄范围：25-66岁），平均体重指数为44.8±4。包括7kg / m 2。其中14人也有间歇性至中度哮喘。在整个人群中，体重指数从44.8±4.7降至41.1±3.9kg / m 2（p \x3d。0001），用力肺活量从3.05±0.83提高到3.50±0.81 L（P \x3d 0.043）。用力呼气量和氧饱和度没有变化。这些结果在分析哮喘和非哮喘时也保持有效。关于一氧化氮，1年的减少是显着不同的两个人口，因为在哮喘患者中，减肥手术后呼出气一氧化氮下降4.86ppb，非哮喘患者呼气中氧化氮增加0.27ppb（p \x3d 0.04）。结论。减肥手术显着降低了哮喘患者吸入皮质类固醇的摄入量以及呼出气一氧化氮（即支气管炎症）的水平。
Carlo Lombardi[1];Sabrina Gargioni[1];Angelo Gardinazzi[2];Giorgio Walter Canonica[3];Giovanni Passalacqua[4]. Impact of Bariatric Surgery on Pulmonary Function and Nitric Oxide in Asthmatic and Non-Asthmatic Obese Patients[J]. Journal of Asthma, 2011,48(6): 553-557