摘要
Cell-mediated immune responses form an important part of the protection against intracellular pathogens. The MHC Class I and Class II antigens are important for the proper presentation of degraded proteins to cytotoxic T lymphocytes (CTL) and helper T cells, respectively. Recent developments in the knowledge of the molecular structure of the MHC in relation to antigen presentation are discussed. Although CTL are important, there is a paucity of information concerning their relevance for the control of viral diseases in poultry. A newly developed approach of stable transfection of viral genes into cell lines transformed by reticuloendotheliosis virus has shown promise as a method to define proteins, which are important for the induction of cell-mediated immunity.
摘要译文
细胞介导的免疫反应形成了对细胞内病原体的保护的重要部分。 MHC I类和II类抗原对于分别将降解蛋白适当呈递给细胞毒性T淋巴细胞（CTL）和辅助T细胞是重要的。讨论了与抗原呈递相关的MHC分子结构知识的最新进展。尽管CTL很重要，但是它们对于控制家禽病毒性疾病的相关性却缺乏信息。将病毒基因稳定转染到由网状内皮组织增殖病毒转化的细胞系中的新开发的方法显示出作为定义蛋白质的方法的前景，所述蛋白质对于诱导细胞介导的免疫是重要的。
KAREL A. SCHAT. Cell-Mediated Immune Effector Functions in Chickens[J]. Poultry Science, 1994,73(7): 1077–1081