摘要
Although the analysis of the enantiomers of chiral non-steroidal anti-inflammatory drugs (NSAIDs) has been carried out for over 20 years, there often remains a deficit within the pharmaceutical and medical sciences to address this issue. Hence, despite world-wide therapeutic use of chiral NSAIDs the importance of stereoselectivity in pharmacokinetic, pharmacodynamic and pharmacological activity and disposition has often been ignored. This review presents both the general principles that allow separation of chiral NSAID enantiomers, and discusses both the advantages and disadvantages of the available chromatographic assay methods and procedures used to separately quantify NSAID enantiomers in biological matrices.
摘要译文
虽然对手性非甾体类抗炎药（NSAIDs）的对映异构体的分析已经进行了20多年，但是在制药和医学科学领域常常存在赤字来解决这个问题。因此，尽管手性NSAID在世界范围内的治疗用途，立体选择性在药代动力学，药效学和药理学活性和处置的重要性往往被忽视。本综述介绍了可分离手性NSAID对映体的一般原理，并讨论了用于单独定量生物基质中NSAID对映体的色谱分析方法和程序的优缺点。
Neal M. Davies. Methods of analysis of chiral non-steroidal anti-inflammatory drugs[J]. Journal of Chromatography B: Biomedical Sciences and Applications, 1997,691(2): 229-261