摘要
A fundamentally new strategy for the treatment of infectious disease is the modulation of host immune responses to enhance clearance of infectious agents and reduce tissue damage due to inflammation. Antimicrobial host defense peptides have been investigated for their potential as a new class of antimicrobial drugs. Recently their immunomodulatory activities have begun to be appreciated. Modulation of innate immunity by synthetic variants of host defense peptides, called innate defense regulators (IDRs), is protective without direct antimicrobial action. We discuss the potential and current limitations in exploiting the immunomodulatory activity of IDRs as a novel anti-infective pathway. IDRs show significant promise and current research is uncovering mechanistic information that will aid in the future development of IDRs for clinical use.
摘要译文
治疗感染性疾病的基本新策略是调节宿主免疫应答以增强感染因子的清除并减少炎症引起的组织损伤。已经研究了抗微生物宿主防御肽作为一类新的抗微生物药物的潜力。最近，他们的免疫调节活动已经开始受到重视。通过宿主防御肽的合成变体调节天然免疫，称为先天防御调节剂（IDR），是保护性的，没有直接的抗微生物作用。我们讨论了利用IDR的免疫调节活性作为一种新的抗感染途径的潜在和当前的局限性。 IDR显示了重大的前景，目前的研究正在揭示机械信息，这将有助于临床使用IDR的未来发展。
Donna M.Easton[1];AnastasiaNijnik[1];Matthew L.Mayer[1][2];Robert E.W.Hancock[1];. Potential of immunomodulatory host defense peptides as novel anti-infectives[J]. Trends in Biotechnology, 2009,27(10): 582-590