摘要
Mitochondria are crucial organelles as their role in cellular energy production of eukaryotes. Because the brain cells demand high energy for maintaining their normal activities, disturbances in mitochondrial physiology may lead to neuropathological events underlying neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. Melatonin is an endogenous compound with a variety of physiological roles. In addition, it possesses potent antioxidant properties which effectively play protective roles in several pathological conditions. Several lines of evidence also reveal roles of melatonin in mitochondrial protection, which could prevent development and progression of neurodegeneration. Since the mitochondrial dysfunction is a primary event in neurodegeneration, the neuroprotection afforded by melatonin is thereby more effective in early stages of the diseases. This article reviews mechanisms which melatonin exerts its protective roles on mitochondria as a potential therapeutic strategy against neurodegenerative disorders. KeywordsMelatonin Mitochondria Neurodegeneration Alzheimer’s disease Parkinson’s disease Huntington’s disease
摘要译文
线粒体是它们在真核生物的细胞能量产生中的关键细胞器。由于脑细胞需要高能量来维持正常的活动，线粒体生理学紊乱可能导致神经退行性疾病如阿尔茨海默氏病，帕金森病和亨廷顿舞蹈症等神经病理学事件。褪黑素是一种具有多种生理作用的内源性化合物。此外，它具有有效的抗氧化性能，在几种病理条件下有效地起到保护作用。几条证据还揭示了褪黑激素在线粒体保护中的作用，其可以阻止神经变性的发展和进展。由于线粒体功能障碍是神经变性的主要事件，所以由褪黑激素提供的神经保护因此在疾病的早期阶段更有效。本文综述了褪黑激素对线粒体发挥保护作用的机制，作为预防神经退行性疾病的潜在治疗策略。关键词褪黑激素线粒体神经变性阿尔茨海默病帕金森病亨廷顿病
Pawaris Wongprayoon [1] Piyarat Govitrapong [2 [3]]. Melatonin as a mitochondrial protector in neurodegenerative diseases[J]. Cellular and Molecular Life Sciences, 2017,74(21): 3999-4014