摘要
1 Introduction Isoflavonoids are a large group of secondary metabolites with diverse biological activities that occur widely in plants, which can be subdivided into isoflavones, isoflavans, isoflavanones, rotenoids, pterocarpans, etc. An overwhelming number of isoflavonoids reported come from the Leguminosae family, and some non-leguminous families such as Moraceae are also relatively abundant in isoflavonoids [1, 2]. Some isoflavans and prenylated isoflavones possess potent biological activities, especially in cytotoxicity [3, 4, 5, 6], anti-inflammatory [7], and neuroprotective activity [8]. As part of a BioBioPha (http://www.chemlib.cn) objective to assemble a large-scale natural product library valuable in the discovery of new drug leads from nature [9, 10, 11, 12], the phytochemical investigations on Spatholobus suberectus (Leguminosae), Flemingia macrophylla (Leguminosae), and Cudrania cochinchinensis (Moraceae) led to the isolation of three new isoflavans 7,4′-dihydroxy-8,2′,3′-trimethoxyisoflavan (1), 7,2′,4′-trihydroxy-8,3′-dimethoxyisoflavan (2), and 7,2′,4′-trihydroxy-5-methoxyisoflavan (3), and one new prenylated isoflavone namely cudraisoflavone M (4), respectively (Fig. 1). Herein we report the structure elucidation of new isoflavonoid and their cytotoxicity evaluation against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480). Open image in new window
摘要译文
[1引言异黄酮是一大批次生代谢产物，具有多种生物活性，广泛存在于植物中，可分为异黄酮，异黄酮，异黄酮，旋叶，叶黄素等。据报道，绝大多数类异黄酮来自豆科，而一些非豆科家族如Moraceae在异黄酮中也相对丰富[1,2] 一些异黄酮和异戊二烯酸化的异黄酮具有很强的生物活性，特别是细胞毒性[3,4,5,6]，抗炎[7]和神经保护活性[8]。作为BioBioPha的一部分（http：// www。hemlib cn）目的是组装一个有价值的大型天然产物库，以发现自然界的新药物[9,10,11,12]对松节虫（Leguminosae），Flemingia macrophylla（豆科）和Cudrania cochinchinensis（Moraceae）的植物化学研究导致三种新异黄酮的分离7，4''''-二羟基-8,2''''，3''''-三甲氧基异视黄素（1），7,2''''，4''''-三羟基-8,3''''-二甲氧基异视黄素（2）和7,2''''，4''''-三羟基-5 - 甲氧基异视黄素（3），和一种新的异戊二烯基异黄酮（即菊酯异黄酮M（4））（图1）本文报道了新型异黄酮的结构阐述及其对五种人类癌细胞株（HL-60，A-549，SMMC-7721，MCF-7和SW-480）的细胞毒性评估在新窗口中打开图片]