摘要
The aim of this study was to evaluate the efficacy of Cervidil®, a prostaglandin E2 (PgE2)-releasing vaginal insert used for induction of cervical ripening and labour in women, to enhance the ease of transcervical artificial insemination (TCAI) in anestrous ewes (June). It was hypothesized that the use of Cervidil® prior to AI would cause dilation of the cervix, and thus alleviate the difficulty associated with traversing the cervix for semen deposition in sheep. Cervidil® was inserted 12 h before insemination in six Rideau-Arcott ewes; six ewes served as untreated controls.
Semen was deposited into the uterus of all six treated ewes but TCAI was possible only in four of the six control ewes. It can be concluded that Cervidil® facilitated transcervical semen deposition in anestrous ewes. The treatment with Cervidil® has the promise of a technique to improve transcervical AI and to enable non-invasive embryo transfer procedures in sheep.
摘要译文
这项研究的目的是评估用于诱导妇女宫颈成熟和分娩的前列腺素E2（PgE2）释放阴道插入物Cervidil®用于增强经宫颈人工授精（TCAI）的容易度的功效，在无情的母羊（六月）。据推测，在AI之前使用Cervidil®会引起子宫颈扩张，从而减轻穿越子宫颈进行精液沉积在羊身上的困难。在6只里多 - 阿尔科特母羊授精前12小时插入Cervidil®/ sup;六只母羊作为未经处理的对照。精液被存放到所有六只处理过的母羊的子宫内，但TCAI仅在六只对照母羊中有四只可能。可以得出结论，Cervidil®促进了宫颈精液在失养母羊中的沉积。 Cervidil®的治疗有望改善经宫颈AI，并能够在羊中实现非侵入性胚胎移植手术。
Ivanka B.R.Candappa;Heidi C.Bainbridge;Nadine T.Price;Kaitlyn R.Hourigan;Pawel M.Bartlewski;. A preliminary study on the suitability of Cervidil® to induce cervical dilation for artificial insemination in ewes[J]. Research in Veterinary Science, 2009,87(2): 204-206