期刊文献

A new genome-scale metabolic model of Corynebacterium glutamicum and its application 收藏

谷氨酸棒状杆菌基因组全新的代谢模型及其应用

原文求助发布源

作者

Yu Zhang [1 [2] Jingyi Cai [3] Xiuling Shang [1] Bo Wang [1 [2] Shuwen Liu [1] Xin Chai [1 [2] Tianwei Tan [3] Yun Zhang [1] Tingyi Wen [1 [4]]

作者单位

[1]CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of MicrobiologyChinese Academy of SciencesBeijingChina [2]University of Chinese Academy of SciencesBeijingChina [3]Beijing University of Chemical TechnologyBeijingChina [4]Savaid Medical SchoolUniversity of Chinese Academy of SciencesBeijingChina

关键词

Corynebacterium glutamicum ;Genome-scale metabolic model ;l;-proline production ;Model-driven experimentation ;Metabolic engineering ;

关键词译文

谷氨酸棒状杆菌;基因组规模的代谢模型; L-脯氨酸生产;模型驱动的实验;代谢工程;

发布日期

30 June 2017

DOI

10.1186/s13068-017-0856-3

来源信息

Biotechnology for Biofuels ISSN：e1754-6834, 2017年, 10卷, 1期

摘要

Background Corynebacterium glutamicum is an important platform organism for industrial biotechnology to produce amino acids, organic acids, bioplastic monomers, and biofuels. The metabolic flexibility, broad substrate spectrum, and fermentative robustness of C. glutamicum make this organism an ideal cell factory to manufacture desired products. With increases in gene function, transport system, and metabolic profile information under certain conditions, developing a comprehensive genome-scale metabolic model (GEM) of C. glutamicum ATCC13032 is desired to improve prediction accuracy, elucidate cellular metabolism, and guide metabolic engineering.

摘要译文

背景技术谷氨酸棒状杆菌（Corynebacterium glutamicum）是工业生物技术用于生产氨基酸，有机酸，生物塑料单体和生物燃料的重要平台生物。谷氨酸棒杆菌的代谢灵活性，广泛的底物谱和发酵稳健性使得该生物体成为理想的细胞工厂以生产所需产物。随着基因功能，转运系统和代谢特征信息在一定条件下的增加，开发谷氨酸棒状杆菌ATCC13032全面的基因组规模代谢模型（GEM），可以提高预测的准确性，阐明细胞代谢，指导代谢工程。

Yu Zhang [1 [2] Jingyi Cai [3] Xiuling Shang [1] Bo Wang [1 [2] Shuwen Liu [1] Xin Chai [1 [2] Tianwei Tan [3] Yun Zhang [1] Tingyi Wen [1 [4]]. A new genome-scale metabolic model of Corynebacterium glutamicum and its application[J]. Biotechnology for Biofuels, 2017,10(1)