摘要
Milk protein-derived peptides have shown immunomodulatory properties either singly or in a mixture. However, information on the behaviour of these compounds is scarce, complicating their further study. This review presents current knowledge on immunomodulatory milk protein-derived peptides, including hydrolysates, peptide fractions and single peptides. The evidence shows that hydrolysates derived from both casein and whey proteins show immunomodulatory effects; however, this bioactivity is mainly attributed to peptides derived from caseins. The identification of peptides in hydrolysates, as well as their characterisation and knowledge of the mechanisms behind their bioactivity, is necessary to further exploit their potential health benefits.
摘要译文
乳蛋白衍生的肽单独或以混合物显示免疫调节性质。然而，这些化合物的行为信息很稀缺，使他们的进一步研究变得复杂。本综述介绍了免疫调节乳蛋白衍生肽的最新知识，包括水解产物，肽级分和单肽。证据表明来源于酪蛋白和乳清蛋白的水解产物显示免疫调节作用;然而，这种生物活性主要归因于来自酪蛋白的肽。水解物中肽的鉴定以及它们的生物活性背后的机制的表征和知识对于进一步利用其潜在的健康益处是必需的。
Aline Reyes-Díaz, Aarón F González-Córdova, Adrián Hernández-Mendoza, Ricardo Reyes-Díaz and Belinda Vallejo-Cordoba[*]. Immunomodulation by hydrolysates and peptides derived from milk proteins[J]. International Journal of Dairy Technology, 2018,71(1): 1-9