摘要
Defensins are a large family of polypeptides occuring in most animals and plants. Since the first description of a defensin in 1985, the members of this peptide class are considered to play an important role in the innate immune defence of organisms, protecting against invading pathogens by killing bacteria and other microbes. In mammals, defensins display a broad functional spectrum, linking them to the adaptive immune system and other functions, and their expression is altered in certain disease states. This review summarises the patents that are associated with defensin peptides and their use as published between 2003 and March 2006.
摘要译文
防御素是在大多数动植物中发生的一大类多肽。自1985年第一次描述防御素以来，该肽类的成员被认为在生物体的先天性免疫防御中发挥重要作用，通过杀死细菌和其他微生物来防止入侵的病原体。在哺乳动物中，防御素显示出广泛的功能谱，将其连接到适应性免疫系统和其他功能上，并且在某些疾病状态下它们的表达被改变。本综述总结了2003年至2006年3月发表的与防卫素肽及其用途有关的专利。
Knut Adermann&EMail:ka@viro-pharma.de[1]. Defensins as anti-infective and immunomodulatory agents[J]. Expert Opinion on Therapeutic Patents, 2006,16(9): 1223-1234