摘要
Antiparasitic and antifungal drugs have not received the same high level of recognition as antimicrobial drugs. They are comparatively few in number, the great majority of them were developed more than a century ago, they have many adverse side effects and are subject to the emergence of drug resistance. The second part of the review, devoted to the immunomodulatory effects of antimicrobial agents, addresses the interference of antiparasitic and antifungal agents with the host natural defenses and the deleterious or beneficial consequences of these properties.
摘要译文
抗寄生虫和抗真菌药物没有得到与抗微生物药物相同的高度认可。它们的数量相对较少,其中绝大多数是在一个多世纪前发展起来的,它们有许多不良副作用并且出现耐药性。该评论的第二部分致力于抗微生物剂的免疫调节作用,涉及抗寄生虫剂和抗真菌剂与宿主天然防御剂的干扰以及这些性质的有害或有益后果。
Marie-Thérèse Labro&EMail:marie-therese.labro@inserm.fr[1]. Immunomodulatory effects of antimicrobial agents. Part II: antiparasitic and antifungal agents[J]. Expert Review of Anti-infective Therapy, 2012,10(3): 341-357