摘要
Will we replace oil with wheat or corn as a feedstock for producing natural plastic? The success of biotechnology for bulk product manufacturing will heavily depend on engineering solutions in the downstream processes in which separation and purification have a crucial role with respect to commercial development. Development of efficient bioseparation methods is important for a broad range of business areas including pharmaceuticals, nutrition and health products, bio-based materials and crop protection chemicals. Depending on the value of the end product and the scale of production, the processing required varies significantly. Key factors that have an impact on the choice of separation strategy include process throughput, particle size of the product and impurities and the desired end-product concentration. The development of efficient, economical and selective separation methods will be required for successful commercialization of bioprocesses. Despite this well-recognized need, there are relatively few available methods for commercial implementations. Development of novel mechanical systems for selective separation of solid and liquid mixtures must become a top priority for current research investment to reduce the reliance on expensive chromatographic and thermal separation methods.
摘要译文
我们会用小麦或玉米取代石油作为生产天然塑料的原料吗？散装产品制造将严重依赖下游工艺中的工程解决方案，其中分离和净化在商业开发方面具有至关重要的作用。高效的生物分离方法的开发对于广泛的业务领域是重要的，包括药物，营养和保健产品，生物基材料和作物保护化学品。根据最终产品的价值和生产规模的不同，所需加工的差异很大。影响分离策略选择的关键因素包括工艺产量，产品粒度和杂质以及所需的最终产品浓度。生物过程的成功商业化将需要开发高效，经济和选择性的分离方法。尽管这个公认的需要，用于商业实现的可用方法相对较少。选择性分离固体和液体混合物必须成为当前研究投资的首要任务，以减少对昂贵的色谱和热分离方法的依赖。
Karsten Keller karsten.keller@usa.dupont.com Thomas Friedmann Arthur Boxman. The bioseparation needs for tomorrow[J]. Trends in Biotechnology, 2001,19(11): 438-441