摘要
Previous studies have suggested that the intake of trans-fatty acids (TFA) plays a role in the development of obesity. The proportions of adipose tissue fatty acids not synthesised endogenously in humans, such as TFA, usually correlate well with the dietary intake. Hence, the use of these biomarkers may provide a more accurate measure of habitual TFA intake than that obtained with dietary questionnaires. The objective of the present study was to investigate the associations between the proportions of specific TFA in adipose tissue and subsequent changes in weight and waist circumference (WC). The relative content of fatty acids in adipose tissue biopsies from a random sample of 996 men and women aged 50–64 years drawn from a Danish cohort study was determined by GC. Baseline data on weight, WC and potential confounders were available together with information on weight and WC 5 years after enrolment. The exposure measures were total trans-octadecenoic acids (18 : 1t), 18 : 1 Δ6-10t, vaccenic acid (18 : 1 Δ11t) and rumenic acid (18 : 2 Δ9c, 11t). Data were analysed using multiple regression with cubic spline modelling. The median proportion of total adipose tissue 18 : 1t was 1·52 % (90 % central range 0·98, 2·19) in men and 1·47 % (1·01, 2·19) in women. No significant associations were observed between the proportions of total 18 : 1t, 18 : 1 Δ6-10t, vaccenic acid or rumenic acid and changes in weight or WC. The present study suggests that the proportions of specific TFA in adipose tissue are not associated with subsequent changes in weight or WC within the exposure range observed in this population. View HTML Send article to Kindle
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Find out more about the Kindle Personal Document Service. Adipose tissue trans-fatty acids and changes in body weight and waist circumference Volume 111, Issue 7 Camilla P. Hansen (a1) (a2) (a3), Tina L. Berentzen (a3), Jane N. Østergaard (a1) (a2), Christina C. Dahm (a1), Lars I. Hellgren (a4), Erik B. Schmidt (a2), Anne Tjønneland (a5), Thorkild I. A. Sørensen (a3) (a6), Kim Overvad (a1) (a2) and Marianne U. Jakobsen (a1) DOI: https://doi.org/10.1017/S0007114513003747 Your Kindle email address Please provide your Kindle email. @free.kindle.com @kindle.com (service fees apply) Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send × Send article to Dropbox
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