摘要
Circadian rhythms optimize physiology and health by temporally coordinating cellular function, tissue function, and behavior. These endogenous rhythms dampen with age and thus compromise temporal coordination. Feeding-fasting patterns are an external cue that profoundly influence the robustness of daily biological rhythms. Erratic eating patterns can disrupt the temporal coordination of metabolism and physiology leading to chronic diseases that are also characteristic of aging. However, sustaining a robust feeding-fasting cycle, even without altering nutrition quality or quantity, can prevent or reverse these chronic diseases in experimental models. In humans, epidemiological studies have shown erratic eating patterns increase the risk of disease, whereas sustained feeding-fasting cycles, or prolonged overnight fasting, is correlated with protection from breast cancer. Therefore, optimizing the timing of external cues with defined eating patterns can sustain a robust circadian clock, which may prevent disease and improve prognosis.
摘要译文
昼夜节律通过时间协调细胞功能，组织功能和行为来优化生理和健康。这些内生的节奏随着年龄而衰减，从而危及时间协调。禁食模式是深刻影响日常生物节律稳健性的外在线索。不规律的饮食模式会破坏新陈代谢和生理机能的时间协调，导致慢性疾病，这也是衰老的特征。然而，即使不改变营养质量和数量，维持一个强大的禁食循环，也可以预防或逆转这些实验模型中的慢性疾病。在人类中，流行病学研究表明，不规律的饮食模式增加了疾病的风险，而持续的禁食 - 禁食周期，或过夜禁食，与防止乳腺癌相关。因此，优化具有限定饮食模式的外部提示的时间可以维持强劲的生物钟，这可能预防疾病并改善预后。
Emily N.C.Manoogian[a];SatchidanandaPanda[a][b];. Circadian rhythms, time-restricted feeding, and healthy aging[J]. Ageing Research Review, 2017,39: 59-67