期刊文献

Physiology of the GH-IGF axis 收藏

在GH-IGF轴生理

原文求助发布源

作者

MARTINELLI JR, Carlos Eduardo; CUSTODIO, Rodrigo José ; AGUIAR-OLIVEIRA, Manuel Hermínio

关键词

GH; IGF-1; IGF-2; IGFBP; IGF1R; Growth.

关键词译文

GH; IGF-1; IGF-2; IGFBP; IGF1R;增长。

页码

717-725

DOI

10.1590/S0004-27302008000500002

来源信息

Arquivos Brasileiros de Endocrinologia & Metabologia ISSN：e1677-9487, 2008年, 52卷, 5期, 717-725页

摘要

Growth, the main characteristic of childhood and adolescence, has a similar pattern in the majority of the individuals. Genetic background and GH-IGF axis are the factors that directly influence this process. Pituitary GH acts on growth mainly through the regulation of IGF system. The IGFs (IGF-1 and IGF-2) are growth factors produced in the majority of the organs and body tissues. They have autocrine, paracrine and endocrine actions on metabolism and cell proliferation, growth and differentiation. The IGFs bind with high specificity and affinity to a family of 6 binding proteins, called IGFBPs (1 to 6) that modulate their bioactivity. Most of the known IGF actions are mediated via IGF type 1 receptor (IGF1R). In this article we are going to review the composition and regulation of the GH-IGF axis and the role of each component in the regulation of the growth process.

摘要译文

增长，儿童期和青少年的主要特征，在大多数个体的类似的模式。遗传背景和GH-IGF轴是直接影响该过程的因素。垂体生长激素作用于增长主要是通过IGF系统的调节。所述胰岛素样生长因子（IGF-1和IGF-2）是在大多数器官和身体组织产生的生长因子。它们对代谢和细胞的增殖，生长和分化的自分泌，旁分泌和内分泌的行动。所述胰岛素样生长因子结合以高特异性和亲和力的一个家族的6结合蛋白，被称为的IGFBPs（1至6），该调节其生物活性。大多数已知的IGF动作经由IGF-1型受体（IGF1R）介导的。在这篇文章中，我们要检讨的组成和GH-IGF轴的调节和每个组件的在成长过程中的调控作用。

MARTINELLI JR, Carlos Eduardo; CUSTODIO, Rodrigo José ; AGUIAR-OLIVEIRA, Manuel Hermínio. Physiology of the GH-IGF axis[J]. Arquivos Brasileiros de Endocrinologia & Metabologia, 2008,52(5): 717-725