期刊文献

Baculovirus as a vaccine vector 收藏

杆状病毒作为疫苗载体

原文求助发布源

作者

Hsin-Yu Lu[1];Yi-Hsuan Chen[1];Hung-Jen Liu[2]

作者单位

[1]Institute of Molecular Biology; National Chung Hsing University; Taichung, Taiwan;[2]Institute of Molecular Biology; National Chung Hsing University; Taichung, Taiwan; Agricultural Biotechnology Center; National Chung Hsing University; Taichung, Taiwan

关键词

: baculovirus; surface display vector; vaccine; VSVG; gp64

关键词译文

：杆状病毒;表面显示矢量;疫苗; VSVG; GP64

发布日期

18 Jun 2012

页码

271-274

DOI

10.4161/bioe.20679

来源信息

Bioengineered ISSN：2165-5979, 2012年, 3卷, 5期, 271-274页

摘要

Baculovirus is extensively utilized as an excellent tool for production of recombinant protein in insect cells. Baculovirus infects insects in nature and is non-pathogenic to humans. In addition to insect cells, baculovirus is capable of transducing a broad range of animal cells. Due to its biosafety, large cloning capacity, low cytotoxicity, and non-replication nature in the transduced cells as well as the ease of manipulation and production, baculovirus has been utilized as RNA interference mediators, gene delivery vectors, and vaccine vectors for a wide variety of applications. This article focuses on the utilization of baculoviruses as vaccine vectors to prepare antigen or subunit vaccines.

摘要译文

杆状病毒被广泛用作在昆虫细胞中产生重组蛋白的优良工具。杆状病毒在自然界感染昆虫，对人类无致病性。除了昆虫细胞之外，杆状病毒还能够转导广泛的动物细胞。由于其生物安全性，大的克隆能力，低细胞毒性和转导细胞中的非复制性质以及易于操作和生产，杆状病毒已被用作RNA干扰介质，基因递送载体和用于广泛的疫苗载体各种应用程序。本文重点介绍利用杆状病毒作为疫苗载体来制备抗原或亚单位疫苗。

Hsin-Yu Lu[1];Yi-Hsuan Chen[1];Hung-Jen Liu[2]. Baculovirus as a vaccine vector[J]. Bioengineered, 2012,3(5): 271-274