摘要
Bisphenol A (BPA), a putative endocrine disruptor, may be taken up by humans via the diet and have adverse effects on human health. In this study, we evaluated whether the probiotics, Bifidobacterium breve strain Yakult (BbY) and Lactobacillus casei strain Shirota (LcS), could exert a protective effect against dietary exposure to BPA. A group of rats fed on a diet containing 5% BbY or 5% LcS showed three advantageous effects compared to the control group; (i) the area under the blood concentration-time curve of BPA after its oral administration was significantly decreased, (ii) the amount of BPA excreted in the feces was significantly greater (2.4 times), and (iii) the percentage of BPA bound to the sediment fraction of the feces was significantly higher. These results suggest that BbY and LcS reduced the intestinal absorption by facilitating the excretion of BPA, and that these probiotics may suppress the adverse effects of BPA on human health.
摘要译文
双酚A（BPA），推定的内分泌干扰物，可以采取由人类通过饮食和对人类健康造成不良影响。在这项研究中，我们评估是否益生菌，双歧杆菌菌株养乐多（BBY）和干酪乳杆菌代田株（LCS），可能会产生对食物摄入BPA有保护作用。一组大鼠喂食含5％BBY或5％LCS表明3有利效果相比于对照组饮食; （ⅰ）双酚A的血中浓度 - 时间曲线后其口服给药显著降低下面积，（ⅱ）双酚A的排泄在粪便中的量为显著更大（2.4倍），和（iii）结合的双酚A的比例到粪便的沉积物分数为显著高。这些结果表明，BBY和LCS减少肠道吸收通过促进BPA的排泄，而这些益生菌可以抑制BPA对人类健康的不良影响。
Kenji OISHI[1]; Tadashi SATO[2]; Wakae YOKOI[2]; Yasuto YOSHIDA[2]; Masahiko ITO[2];Haruji SAWADA[2]. Effect of Probiotics, Bifidobacterium breve and Lactobacillus casei, on Bisphenol A Exposure in Rats[J]. Bioscience, Biotechnology, and Biochemistry, 2008,72(6): 1409-1415