摘要
Natural cationic host defence (antimicrobial) peptides are widely distributed gene encoded molecules with diverse structures. There are more than 1200 natural Host Defence Peptides (HDPs) described to date. Due to the multifunctional roles defined for such peptides there is a keen interest in the potential therapeutic applications of HDPs and their synthetic mimics, Antimicrobial peptides and Innate Defence Regulator (IDR) peptides. These peptides constitute two broad classes of potential therapeutics; (i) with direct antimicrobial and/or anti-biofilm activity, and (ii) with immune-modulating and/or anti-inflammatory activity. Exploiting the immunomodulatory functions of these peptides represents a new therapeutic approach for resolution of infections and inflammatory disorders.
摘要译文
天然阳离子宿主防御（抗微生物）肽是广泛分布的具有不同结构的基因编码分子。迄今为止描述了超过1200种天然宿主防御肽（HDP）。由于对这些肽定义的多功能作用，人们对HDP及其合成模拟物，抗微生物肽和先天防御调节剂（IDR）肽的潜在治疗应用具有浓厚的兴趣。这些肽构成两大类潜在的治疗方法; （i）具有直接抗微生物和/或抗生物膜活性，和（ii）具有免疫调节和/或抗炎活性。利用这些肽的免疫调节功能代表了解决感染和炎性疾病的新治疗方法。
Neeloffer Mookherjee1, Leola N. Y. Chow1, Robert E. W. Hancock*2. Immunomodulatory Cationic Peptide Therapeutics: A New Paradigm in Infection and Immunity. Small Wonders: Peptides for Disease Control[M].US: ACS, 2012: 1-19