摘要
Epidemiological evidence suggesting a negative correlation between carotenoid intake and cancer incidence drew considerable attention to these micronutrients as potential chemopreventive agents1,2,3. In addition, the beneficial effect of beta-carotene in treatment of photosensitive diseases stimulated its use in pharmacological doses for therapeutic purposes4,5. There is evidence from animal experiments that beta-carotene is capable of reducing cancer development6,7. Currently, a number of investigators are conducting prospective intervention studies using beta-carotene as a chemopreventive agent against a variety of human precancerous conditions in high-risk populations8.
摘要译文
流行病学证据表明，类胡萝卜素摄入量与癌症发病率呈负相关关系，这些微量营养素作为潜在的化学预防剂 1,2,3 引起了相当大的关注。此外，β-胡萝卜素在治疗光敏性疾病中的有益作用刺激了其在药理学剂量中用于治疗目的 4,5 。来自动物实验的证据表明β-胡萝卜素能够减少癌症发展 6,7 。目前，许多研究人员正在进行前瞻性干预研究，使用β-胡萝卜素作为化学预防剂，对抗高风险人群中的各种人类癌前病症 8 。
Nikolay V. Dimitrov[1];Duane E. Ullrey[1]. Bioavailability of Carotenoids. Carotenoids[M].DE: Springer, 1989: 269-277